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List of substances for condition Group: Brain

All Human Animal Risk/Association ReviewRows: 617

Substance InfoDose WarnLink PubMed
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Curcumin 📋✍⛔38687459Curcumin attenuates brain aging by reducing apoptosis and oxidative stress
Melatonin 📋✍⛔38561619The Therapeutic Potential of Melatonin in Alzheimer's Disease: A Comprehensive Review
Ginsenosides 📋✍⛔38705107Synergistic promotion of angiogenesis after intracerebral hemorrhage by ginsenoside Rh2 and chrysophanol in rats
Resveratrol 📋✍⛔38546908Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway
Cannabidiol 📋✍⛔38590254Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis
Vitamin D3 📋✍⛔38598329Co-administration of probiotic and vitamin D significantly improves cognitive function in schizophrenic patients: A double-blinded randomized controlled trial
Berberine 📋✍⛔38727934Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats
Ginkgo Biloba 📋✍⛔38654507Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease
Omega-3 Fatty Acids 📋✍⛔38470647Omega-3 Fatty Acids for Depression in the Elderly and Patients with Dementia: A Systematic Review and Meta-Analysis
Quercetin 📋✍⛔38692425Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice
Ginseng 📋✍⛔38707644Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia
Vitamin C 📋✍⛔38718917Ascorbic acid supplementation improves adolescent stress-induced cognitive impairment through restoration of behavioral, biochemical and electrophysiological alterations in male rats
Astragalosides 📋✍⛔38621909[Mechanism of astragaloside â…£ combined with Panax notoginseng saponins in regulating angiogenesis to treat cerebral ischemia based on network pharmacology and experimental verification]
EGCG 📋✍⛔38427657Epigallocatechin gallate improves neuronal damage in animal model of ischemic stroke and glutamate-exposed neurons via modulation of hippocalcin expression
Citicoline 📋✍⛔38383902Synergistic antidepressant-like effect of citicoline and CB 1 agonist in male mice
Ginkgolides 📋 38676673[Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease]
Magnesium 📋✍⛔38514031Early intravenous magnesium sulfate and its impact on cerebral vasospasm as well as delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: A retrospective matched case-control analysis
Astaxanthin 📋✍⛔38542737The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review
Luteolin 📋✍⛔38203299Role of Luteolin as Potential New Therapeutic Option for Patients with Glioblastoma through Regulation of Sphingolipid Rheostat
Sulforaphane 📋✍⛔38438062Sulforaphane's role in Redefining autophagic Responses in depression associated with polycystic ovarian syndrome: Unveiling the SIRT1/AMPK/LKB1 pathway connection
Saffron 📋✍⛔37801956The effect of saffron and corrective exercises on depression and quality of life in women with multiple sclerosis: A randomized controlled clinical trial
Salidroside 📋 38643543Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway
CoQ10 📋✍⛔38684047Discovering the Potential Value of Coenzyme Q10 as an Adjuvant Treatment in Patients With Depression
Metformin 📋✍⛔38582410The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats
Crocin 📋✍⛔38227208Interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of Alzheimer's disease
N-Acetyl Cysteine 📋✍⛔38299014Treatment effects of N-acetyl cysteine on resting-state functional MRI and cognitive performance in patients with chronic mild traumatic brain injury: a longitudinal study
Genistein 📋✍⛔38275516Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease
Docosahexaenoic Acid 📋✍⛔38676880Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS
Puerarin 📋✍⛔38412923Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation
Vitamin B12 📋✍⛔38715940Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice
Acetyl-L-Carnitine 📋✍⛔38155210Investigation of the effect of carnitine on cerebral vasospasm in experimental subarachnoid hemorrhage model
Micronutrients 📋 ⛔38623983Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
Apigenin 📋✍⛔38007051Protective Effects of Apigenin on the Brain Transcriptome with Aging
Ashwagandha 📋✍⛔38140274Effects of Withania somnifera on Cortisol Levels in Stressed Human Subjects: A Systematic Review
Caffeine 📋✍⛔38542677The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial
Lipoic Acid 📋✍⛔38305103Alpha-lipoic acid (ALA) ameliorates early brain injury after subarachnoid hemorrhage in Sprague-Dawley (SD) rats via inhibiting STING-NLRP3 inflammatory signaling
Baicalin 📋✍⛔38631145Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment
Vitamin E 📋✍⛔38542534Tocotrienols Prevent the Decline of Learning Ability in High-Fat, High-Sucrose Diet-Fed C57BL/6 Mice
Vitamin B9 📋✍⛔38700503Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Gotu Kola 📋✍⛔38703344Hydroalcoholic Extract of Centella asiatica and Madecassic Acid Reverse Depressive-Like Behaviors, Inflammation and Oxidative Stress in Adult Rats Submitted to Stress in Early Life
Medicinal Plants 📋 38425647The efficacy and safety of Chinese herbal medicine for mild cognitive impairment: a systematic review and meta-analysis of randomized placebo-controlled trials
Selenium 📋✍⛔38707461Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack
Baicalein 📋✍⛔38006681Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease
Goji Berry 📋✍⛔38653878Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer's Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
Pterostilbene 📋✍⛔38354494Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling
Schisandra 📋✍⛔38565361Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice
Thymoquinone 📋 ⛔38325603Thymoquinone regulates microglial M1/M2 polarization after cerebral ischemia-reperfusion injury via the TLR4 signaling pathway
Hesperidin 📋✍⛔38107143Hesperidin reduces depressive symptoms in post-coronary artery bypass graft patients with mild depression
Food 📋 38515359Effect of Dietary Habits on Alzheimer's Disease Progression
Andrographolide 📋 37179044Andrographolide exerts a neuroprotective effect by regulating the LRP1-mediated PPARγ/NF-κB pathway
Chrysin 📋✍⛔38555815Chrysin inhibits ferroptosis of cerebral ischemia/reperfusion injury via regulating HIF-1α/CP loop
Ellagic Acid 📋✍⛔38291199Oral administration of ellagic acid mitigates perioperative neurocognitive disorders, hippocampal oxidative stress, and neuroinflammation in aged mice by restoring IGF-1 signaling
Phytochemicals 📋 38519585The predictive role of the dietary phytochemical index in relation to the clinical and psychological traits of migraine headaches
Icariin 📋✍ 38706972Icariin inhibits apoptosis in OGD-induced neurons by regulating M2 pyruvate kinase
Salvianolic Acid 📋 38468280Salvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-κB pathway
Fisetin 📋✍⛔38452414Fisetin alleviates cerebral ischemia/reperfusion injury by regulating Sirt1/Foxc1/Ubqln1 pathway-mediated proteostasis
Dihydromyricetin 📋✍⛔37603215Dihydromyricetin Alleviates Ischemic Brain Injury by Antagonizing Pyroptosis in Rats
Ferulic Acid 📋✍⛔38487137Protective Effect of Ferulic Acid on Acetylcholinesterase and Amyloid Beta Peptide Plaque Formation in Alzheimer's Disease: An In Vitro Study
Nobiletin 📋✍ 37598127The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism
Blueberry 📋✍⛔37647279Blueberry extracts antagonize Aβ25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus
Eicosapentaenoic Acid 📋✍⛔38680120Eicosapentaenoic acid activates the P62/KEAP1/NRF2 pathway for the prevention of diabetes-associated cognitive dysfunction
Naringin 📋✍⛔38457013Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia-Reperfusion Model of Rats
L-Theanine 📋✍⛔37815006Effect of single or combined caffeine and L-Theanine supplementation on shooting and cognitive performance in elite curling athletes: a double-blind, placebo-controlled study
Naringenin 📋✍⛔38561101Liraglutide and Naringenin relieve depressive symptoms in mice by enhancing Neurogenesis and reducing inflammation
Rutin 📋✍⛔38248305Flavonoid Rutin Presented Anti-Glioblastoma Activity Related to the Modulation of Onco miRNA-125b Expression and STAT3 Signaling and Impact on Microglia Inflammatory Profile
Lavender Essential Oil 📋✍⛔36429972Relaxing Effects of Breathing Pseudotsuga menziesii and Lavandula angustifolia Essential Oils on Psychophysiological Status in Older Adults
Walnut 📋 ⛔37814808Gut microbiome and brain transcriptome analyses reveal the effect of walnut oil in preventing scopolamine-induced cognitive impairment
Lycopene 📋✍⛔37871231Lycopene Prevents Phthalate-Induced Cognitive Impairment via Modulating Ferroptosis
Olive Oil 📋✍⛔38339193Extra-Virgin Olive Oil in Alzheimer's Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies
Piperine 📋✍⛔38082237The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial
Boswellic Acid 📋✍⛔37248896Boswellic Acids Improve Clinical Cognitive Scores and Reduce Systemic Inflammation in Patients with Mild to Moderate Alzheimer's Disease
Fish Oil 📋✍⛔37769277Attenuation of Chronic Stress-Induced Depressive-like Symptoms by Fish Oil via Alleviating Neuroinflammation and Impaired Tryptophan Metabolism in Aging Rats
Green Tea 📋✍⛔38308353Green tea consumption and incidence of cardiovascular disease in type 2 diabetic patients with overweight/obesity: a community-based cohort study
NMN 📋✍⛔37931707Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice
Reishi Mushrooms 📋✍⛔38720773Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease
Vitamin B6 📋✍⛔38432716Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
Cocoa 📋✍⛔38268830The effects of dark chocolate on cognitive performance during cognitively demanding tasks: A randomized, single-blinded, crossover, dose-comparison study
Geniposide 📋 38402902Geniposide ameliorates brain injury in mice with intracerebral hemorrhage by inhibiting NF-κB signaling
Pomegranate 📋 ⛔38074891A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease
Probiotics 📋✍⛔38645104Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice
Zinc 📋✍⛔38707461Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack
Chlorogenic Acid 📋✍⛔38429854Chlorogenic acid regulates the expression of protein phosphatase 2A subunit B in the cerebral cortex of a rat stroke model and glutamate-exposed neurons
Frankincense 📋✍⛔38250661Autophagy machinery plays an essential role in traumatic brain injury-induced apoptosis and its related behavioral abnormalities in mice: focus on Boswellia Sacra gum resin
Gallic Acid 📋 ⛔38549642Gallic Acid Alleviates Cognitive Impairment by Promoting Neurogenesis via the GSK3β-Nrf2 Signaling Pathway in an APP/PS1 Mouse Model
Paeoniflorin 📋 38178130Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke
Astragalus Root 📋✍⛔38588987Mechanism of Astragalus mongholicus Bunge ameliorating cerebral ischemia-reperfusion injury: Based on network pharmacology analysis and experimental verification
Polyphenols 📋 38306547Progress of plant polyphenol extracts in treating depression by anti-neuroinflammatory mechanism: A review
Tanshinone 📋 38659601Tanshinone IIA improves Alzheimer's disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis
Allicin 📋✍⛔37973218Therapeutic effect of allicin in a mouse model of intracerebral hemorrhage
Coconut Oil 📋 ⛔38106629Assessment of the neuroprotective effect of Cocos nucifera L. oil on learning and behavior impairment in ovariectomized rats
Folate 📋✍⛔37707697Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways
Grape Seed extract 📋✍⛔36059517Antioxidant effect of grape seed extract corrects experimental autoimmune encephalomyelitis behavioral dysfunctions, demyelination, and glial activation
Carvacrol 📋✍⛔37666857Carvacrol decreases blood-brain barrier permeability post-diffuse traumatic brain injury in rats
Cinnamon 📋✍⛔38696678Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice
Silibinin 📋✍ 38106632Silibinin effects on cognitive disorders: Hope or treatment?
St. Johns Wort 📋✍⛔38684848St. John's wort extract Ze 117 alters the membrane fluidity of C6 glioma cells by influencing cellular cholesterol metabolism
Angelica 📋✍⛔38154524Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice
Anthocyanins 📋✍⛔38455191Higher anthocyanin intake is associated with lower depressive symptoms in adults with and without major depressive disorder
Fucoidan 📋✍⛔38240036Ultrastructural and immunohistochemical insights on the anti-glioma effects of a dual-drug cocktail in an in vivo experimental model
Green Tea Polyphenols 📋✍⛔38136170Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
TUDCA 📋✍⛔38440398Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer's disease
Coffee 📋✍⛔38714417Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities
Dihydroquercetin 📋 38694040Pharmacological investigation of taxifolin for its therapeutic potential in depression
Ginger 📋✍⛔38397589Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets
Kaempferol 📋✍⛔38587532Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice
Pine Bark 📋✍⛔38299491Pycnogenol® improves cognitive function in post-stroke patients: a 6 month-study
Vitamin B2 📋✍⛔38204302Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study
Flavonoids 📋 ⛔38487170Novel insight into the therapeutical potential of flavonoids from traditional Chinese medicine against cerebral ischemia/reperfusion injury
Formononetin 📋 38452845Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway
Fucoxanthin 📋✍⛔37965135Fucoxanthin ameliorates traumatic brain injury by suppressing the blood-brain barrier disruption
Hydroxytyrosol 📋 38680105Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy via HDAC1/2 inhibition
Lemon Balm 📋✍⛔38008959Memory and cognition enhancing effects of combination of Melissa officinalis and Panax ginseng
Nigella Sativa 📋✍⛔38379607Black seed oil reverses chronic antibiotic-mediated depression and social behaviour deficits via modulation of hypothalamic mitochondrial-dependent markers and insulin expression
Rosmarinic Acid 📋✍ 38103880Rosmarinic acid against cognitive impairment via RACK1/HIF-1α regulated microglial polarization in sepsis-surviving mice
Antioxidants 📋 ⛔38578890Association Between Composite Dietary Antioxidant Index and Cognitive Function Among Aging Americans from NHANES 2011-2014
Galangin 📋 36834819Galangin Rescues Alzheimer's Amyloid-β Induced Mitophagy and Brain Organoid Growth Impairment
L-Carnitine 📋✍⛔38674921L-Carnitine in the Treatment of Psychiatric and Neurological Manifestations: A Systematic Review
Ligustilide 📋 38021448Anti-Glioma Effects of Ligustilide or n-Butylphthalide on Their Own and the Synergistic Effects with Temozolomide via PI3K/Akt Signaling Pathway
Ollive Leaf extract 📋✍⛔38153337Expression of Na+/Ca2+ exchangers were enhanced following pre-treatment of olive leaf extract and olive oil in animal model of ischemic stroke
Schisandrins 📋 38285214Schizandrin A attenuates early brain injury following subarachnoid hemorrhage through suppressing neuroinflammation
Scutellarin 📋 38219378Mechanism of scutellarin inhibition of astrocyte activation to type A1 after ischemic stroke
Silymarin 📋✍⛔38353101Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease
Skullcap 📋✍⛔38645989Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease
Taurine 📋✍⛔38616233Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage
Urolithins 📋 38360072Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome in response to neuroinflammation
Asiatic Acid 📋 33802221Asiatic Acid Prevents Cognitive Deficits by Inhibiting Calpain Activation and Preserving Synaptic and Mitochondrial Function in Rats with Kainic Acid-Induced Seizure
Bilobalide 📋 37615035Suppressive effects of bilobalide on depression-like behaviors induced by chronic unpredictable mild stress in mice
Catalpol 📋 38522312Catalpol attenuates ischemic stroke by promoting neurogenesis and angiogenesis via the SDF-1α/CXCR4 pathway
Holy Basil 📋✍⛔37763282Ocimum sanctum Alters the Lipid Landscape of the Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in a Mouse Model
Lutein 📋✍⛔35752349Effect of macular pigment carotenoids on cognitive functions: A systematic review
Moringa Oleifera 📋✍⛔38633104Comparative Neuroprotective Effects of Moringa oleifera Seed Oil and Aqueous Extract on Cognitive Functions on a High-Fat, High-Fructose Diet Mice: Focus on Senescence Markers
Mulberry 📋 ⛔38612872Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays
Vitamin B Complex 📋 ⛔38011468B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial
Aged Garlic 📋✍⛔35805955Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease
Arctigenin 📋 38104254Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism
Carotenoids 📋✍⛔37502714The protective effect of serum carotenoids on cardiovascular disease: a cross-sectional study from the general US adult population
Choline 📋✍⛔37340479Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study
Emodin 📋 ⛔38405501Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer's Dementia: A Systematic Review
Gingerol 📋✍ 38665422In vivo protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways
Hesperetin 📋 38517352Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids
Honokiol 📋 37481555SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes
Mangiferin 📋 ⛔37376018The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment
Nicotinamide Riboside 📋✍⛔38723719Nicotinamide riboside alleviates brain dysfunction induced by chronic cerebral hypoperfusion via protecting mitochondria
Bacopa Monnieri 📋✍⛔38538390Evaluating the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment: A triple-blinded, randomized, placebo-controlled trial
L-Carnosine 📋✍⛔38664193Carnosine ameliorates postoperative cognitive dysfunction of aged rats by limiting astrocytes pyroptosis
Rosemary 📋✍⛔38419891Neuroprotective effects of rosemary extract on white matter of prefrontal cortex in old rats
Sage 📋✍⛔35137748Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model
Tangeretin 📋 38074289Tangeretin confers neuroprotection, cognitive and memory enhancement in global cerebral ischemia in rats
Tea 📋 38714417Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities
Zeaxanthin 📋✍⛔38467357Zeaxanthin impairs angiogenesis and tumor growth of glioblastoma: An in vitro and in vivo study
Artemisinin 📋 38454322Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice
Bee Propolis 📋✍⛔38583392Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice
Betaine 📋✍⛔38145759Betaine eliminates CFA-induced depressive-like behaviour in mice may be through inhibition of microglia and astrocyte activation and polarization
Black Pepper 📋✍⛔36435434Effects of dichloromethane extraction from Piper nigrum L. and P. longum L. on the expression of autophagy-related proteins in ischemic stroke
Icaritin 📋 37990437Icaritin greatly attenuates β-amyloid-induced toxicity in vivo
L-Tryptophan 📋✍⛔36159806Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders
Licorice Root 📋✍⛔38074876Antidepressant effect of licorice total flavonoids and liquiritin: A review
Oleuropein 📋 36836827Olea europaea Leaf Phenolics Oleuropein, Hydroxytyrosol, Tyrosol, and Rutin Induce Apoptosis and Additionally Affect Temozolomide against Glioblastoma: In Particular, Oleuropein Inhibits Spheroid Growth by Attenuating Stem-like Cell Phenotype
Stinging Nettle 📋✍⛔35738179Resistance training and Urtica dioica increase neurotrophin levels and improve cognitive function by increasing age in the hippocampus of rats
Valerian Root 📋✍⛔36829235Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway
Aspirin 📋 ⛔38039031Comprehensive systematic review and meta-analysis on anticoagulants and aspirin for stroke prevention in non-valvular atrial fibrillation patients
Chokeberry 📋✍⛔38656355Short-term Aronia melanocarpa extract supplementation improves cognitive performance: a randomized, double-blind, placebo-controlled cross-over study in healthy young adults
Crocetin 📋 38433503Crocetin protects mouse brain from apoptosis in traumatic brain injury model through activation of autophagy
Glycyrrhizic Acid 📋✍⛔38453099Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1/2-dependent pathways
Grape 📋 ⛔36342065Grape juice reduces the effects of amyloid β aggregation phenotype and extends the longevity in Caenorhabditis elegans
L-Arginine 📋✍⛔37660966Protective effects of L-arginine on Alzheimer's disease: Modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model
Persimmon 📋 ⛔37115470Therapeutic effects of a standardized-flavonoid Diospyros kaki L.f. leaf extract on transient focal cerebral ischemia-induced brain injury in mice
Rapamycin 📋✍ 38640155Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies
Red Sage 📋✍⛔38036060Uncovering Mechanism and Efficacy of Salvia Miltiorrhiza-Safflower in Cerebral Ischemia-Reperfusion Injury
Spirulina 📋✍⛔36861852The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double-blind, controlled trial
Asiaticoside 📋 37569347Asiaticoside Mitigates Alzheimer's Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function
Cordycepin 📋 38294969Dose-dependent action of cordycepin on the microbiome-gut-brain-adipose axis in mice exposed to stress
Diosmin 📋✍⛔38092305Diosmin ameliorates LPS-induced depression-like behaviors in mice: Inhibition of inflammation and oxidative stress in the prefrontal cortex
Lion's Mane Mushrooms 📋✍⛔38539904The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways
Magnolol 📋 38183534The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice
Spikenard 📋✍⛔35864434Jatamansinol from Nardostachys jatamansi Ameliorates Tau-Induced Neurotoxicity in Drosophila Alzheimer's Disease Model
Thymol 📋✍⛔36808768Thymol in Trachyspermum ammi seed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine-induced Alzheimer's disease mouse model
Wogonin 📋✍⛔38253131Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1
Alpha-Linolenic Acid 📋✍⛔38435630Alpha-Linolenic Acid Ameliorates Cognitive Impairment and Liver Damage Caused by Obesity
Calycosin 📋 38461458Calycosin (CA) inhibits proliferation, migration and invasion by suppression of CXCL10 signaling pathway in glioma
Catechins 📋 34220446Oral (-)-Epicatechin Inhibits Progressive Tau Pathology in rTg4510 Mice Independent of Direct Actions at GSK3β
DHEA 📋✍⛔38183866Cortisol and changes in depressive symptoms: The moderating role of DHEA
Ganoderic Acid 📋 38723681Ganoderic acid A ameliorates depressive-like behaviors in CSDS mice: Insights from proteomic profiling and molecular mechanisms
Garlic 📋✍⛔38563400The association between raw garlic consumption and the risk of depressive symptoms: the TCLSIH cohort study
Nicotinamide 📋✍⛔37775016Nicotinamide, an acetylcholinesterase uncompetitive inhibitor, protects the blood‒brain barrier and improves cognitive function in rats fed a hypercaloric diet
Nuts 📋 ⛔37542950Nut consumption is associated with a lower risk of depression in adults: A prospective analysis with data from the UK Biobank cohort
Peony 📋 ⛔37474737Enhanced neuronal activity by suffruticosol A extracted from Paeonia lactiflora via partly BDNF signaling in scopolamine-induced memory-impaired mice
Prebiotics 📋✍⛔38519181Prebiotics modulate the microbiota-gut-brain axis and ameliorate anxiety and depression-like behavior in HFD-fed mice
Pregnenolone 📋✍⛔35721911Pregnenolone Attenuates the Ischemia-Induced Neurological Deficit in the Transient Middle Cerebral Artery Occlusion Model of Rats
Punicalagin 📋✍⛔37092799Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice
Rhodiola 📋✍⛔35745023The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence
Wormwood 📋✍⛔36999542Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation
5-HTP 📋✍⛔37421347Effects of adjuvant berberine therapy on acute ischemic stroke: A meta-analysis
Aloe-Emodin 📋 38621328Aloe-emodin alleviates cerebral ischemia-reperfusion injury by regulating microglial polarization and pyroptosis through inhibition of NLRP3 inflammasome activation
Bee Venom 📋✍⛔38252207Melitoxin Inhibits Proliferation, Metastasis, and Invasion of Glioma U251 Cells by Down-regulating F2RL1
Carnosic Acid 📋 36331794Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2/HO-1 Pathway
Cinnamaldehyde 📋 37174677Disruption of Glioblastoma Multiforme Cell Circuits with Cinnamaldehyde Highlights Potential Targets with Implications for Novel Therapeutic Strategies
Echinacoside 📋 38569512Beneficial effects of Echinacoside on cognitive impairment and diabetes in type 2 diabetic db/db mice
Eugenol 📋 38444813Protective role of Eugenol against the destructive effects of lead on conditioned fear memory in male rats with post-traumatic stress disorder-related behavioral traits
Fenugreek 📋✍⛔37231762Pharmacological attributes of Fenugreek with special reference to Alzheimer's disease
Fish 📋 ⛔38676880Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS
Myricetin 📋 ⛔38423257Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats
Pomegranate Peel extract 📋✍⛔33382357Pomegranate peel extract ameliorates the severity of experimental autoimmune encephalomyelitis via modulation of gut microbiota
Progesterone 📋✍⛔38140038Neuroprotective-Neurorestorative Effects Induced by Progesterone on Global Cerebral Ischemia: A Narrative Review
Bergamot Essential Oil 📋✍⛔38553964Bergamot essential oil improves CUMS-induced depression-like behaviour in rats by protecting the plasticity of hippocampal neurons
Beta-Carotene 📋✍⛔36982248β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure
Biochanin A 📋 38360888Exploring the therapeutic mechanisms and prognostic targets of Biochanin A in glioblastoma via integrated computational analysis and in vitro experiments
Caffeic Acid 📋✍⛔37864768Implication of Caffeic Acid for the Prevention and Treatment of Alzheimer's Disease: Understanding the Binding with Human Transferrin Using In Silico and In Vitro Approaches
Capsaicin 📋✍⛔37373321A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease
Chamomile Essential Oil 📋✍⛔38229887Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease
Diosgenin 📋 38282757Antipsychotic effect of diosgenin in ketamine-induced murine model of schizophrenia: Involvement of oxidative stress and cholinergic transmission
Fo-Ti Root 📋✍⛔38623977Exploring the Constituents and Mechanisms of Polygonum multiflorum Thunb. in Mitigating Ischemic Stroke: A Network Pharmacology and Molecular Docking Study
Gardenia 📋 ⛔38000495Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome
Geraniol 📋 38517361Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model
Haritaki 📋✍⛔38329710Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study
Hawthorn 📋✍⛔36447359Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model
Hyperoside 📋 37609123Vasoprotective Effects of Hyperoside against Cerebral Ischemia/Reperfusion Injury in Rats: Activation of Large-Conductance Ca2+-Activated K+ Channels
Indian Gooseberry 📋 ⛔36738163Preventive effect of Indian gooseberry (Phyllanthus emblica L.) fruit extract on cognitive decline in high-fat diet (HFD)-fed rats
Irisin 📋 38658376Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases
Mushrooms 📋 ⛔38634265Investigating the association between inflammation mediated by mushroom consumption and mild cognitive impairment in Chinese older adults
Neferine 📋 38428144Nrf2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage through inhibiting TAK1-NF-κB signaling
Pomegranate Seed extract 📋 ⛔38306046The Effects of Pomegranate Seed Oil on Mild Cognitive Impairment
Rosemary Essential Oil 📋✍⛔36986277Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition
Sesamol 📋 37848698Sesamol defends neuronal damage following cerebral ischemia/reperfusion: a crosstalk of autophagy and Notch1/NLRP3 inflammasome signaling
Tetrahydrocurcumin 📋✍ 38368289Tetrahydrocurcumin Protects Against GSK3β/PTEN/PI3K/Akt-Mediated Neuroinflammatory Responses and Microglial Polarization Following Traumatic Brain Injury
Tribulus Terrestris 📋✍⛔37876150Dietary Supplement with Tribulus terrestris L. Extract Exhibits Protective Effects on Ischemic Stroke Rats
Vitamin B1 📋✍⛔38367708Association between thiamine intake and depression: A national cross-sectional study
Vitamin B3 📋✍⛔37723526Dietary niacin intake in relation to depression among adults: a population-based study
Acacetin 📋 38114218[Acacetin protects rats from cerebral ischemia-reperfusion injury by regulating TLR4/NLRP3 signaling pathway]
Daidzein 📋✍⛔37619620Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies
Escin 📋✍⛔37716034Escin avoids hemorrhagic transformation in ischemic stroke by protecting BBB through the AMPK/Cav-1/MMP-9 pathway
Galangal 📋✍⛔36306920Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression
Ginger extract 📋✍⛔34679261Zingiber officinale (Ginger) hydroalcoholic extract improved avoidance memory in rat model of streptozotocin-induced diabetes by regulating brain oxidative stress
Ginkgetin 📋 35593977Ginkgetin Promotes M2 Polarization of Microglia and Exert Neuroprotection in Ischemic Stroke via Modulation of PPARγ Pathway
Kudzu Root 📋✍⛔36330645Research on the material basis and mechanism of Kudzu root in preventing and treating cerebral ischemia based on network pharmacology
Lotus 📋 ⛔36757040Procyanidins extracted from the lotus seedpod ameliorate cognitive impairment through CREB-BDNF pathway mediated LTP in APP/PS1 transgenic mice
Mangosteen 📋✍⛔35415207Effects of water-soluble mangosteen extract on cognitive function and neuropsychiatric symptoms in patients with mild to moderate Alzheimer's disease (WECAN-AD): A randomized controlled trial
Patchouli 📋✍⛔38419848Pogostemon cablin essential oil affects anxiety- and depressive-like behaviors and the gut microbiota in chronic unpredictable mild stress model rats
PEA 📋✍⛔38399360Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants-A Double-Blind Randomised Controlled Study
PUFA 📋 34440053Mental Health in Childhood and Adolescence: The Role of Polyunsaturated Fatty Acids
Roselle 📋✍⛔38193451An extract of Hibiscus sabdariffa improves short-term memory in rats with experimental diabetic hyperglycemia
SAMe 📋✍⛔38675528Antitumoral Activity of the Universal Methyl Donor S-Adenosylmethionine in Glioblastoma Cells
Senolytics 📋 38076538Cellular senescence in brain aging and cognitive decline
Soy Isoflavones 📋✍⛔37009142Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination
Turmeric 📋✍⛔35674299Neuroprotective potential of curcuminoids in modulating Alzheimer's Disease via multiple signaling pathways
Ursolic Acid 📋✍⛔38501006Ursolic acid inhibits glioblastoma through suppressing TGFβ-mediated epithelial-mesenchymal transition (EMT) and angiogenesis
Withaferin A 📋 36453416Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
Anise 📋✍⛔37727035Protective effects of anise in prevention of cerebral ischemia reperfusion injury in rats
Balloon Flower 📋✍⛔38491972Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K/Akt/GSK3β Signaling Pathway
Basil 📋✍⛔36185698A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress
BCAA 📋✍⛔36060454Branched-Chain Amino Acids Are Neuroprotective Against Traumatic Brain Injury and Enhance Rate of Recovery: Prophylactic Role for Contact Sports and Emergent Use
CAPE 📋 36978961Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery
Dihydroartemisinin 📋 38552734Dihydroartemisinin protects mice from CUMS-induced depression-like behaviors and regulates gut microbes
Guggulsterone 📋 37230158Novel synergistic mechanism of 11-keto-β-boswellic acid and Z-Guggulsterone on ischemic stroke revealed by single-cell transcriptomics
Linalool 📋 ⛔38723901Linalool acts as a chemical chaperone by inhibiting amyloid-β aggregation
Liquiritin 📋 38074876Antidepressant effect of licorice total flavonoids and liquiritin: A review
Morin 📋 38423257Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats
Paeonol 📋 37164258Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3β-NF-κB signalling pathway in MK-801-treated mice
Peppermint Essential Oil 📋✍⛔37730471Randomized Trial Examining Efficacy of Mentha piperita in Reducing Chronic Headache Discomfort in Youth
PQQ 📋✍⛔38454653Deep Learning-Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease
Spermidine 📋 38648866CaMKIIα mediates spermidine-induced memory enhancement in rats: A potential involvement of PKA/CREB pathway
Stigmasterol 📋 38461353Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles
Strawberry 📋✍⛔35766389Impact of different processing methods on the phenolics and neuroprotective activity of Fragaria ananassa Duch. extracts in a D-galactose and aluminum chloride-induced rat model of aging
Tannic Acid 📋✍⛔37712018A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease
Trehalose 📋 ⛔37549864Effect of trehalose on miR-132 and SIRT1 in the hippocampus of aged rats
Vitamin A 📋✍⛔36728544Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation
Vitexin 📋 38453699Vitexin enhances radiosensitivity of mouse subcutaneous xenograft glioma by affecting the miR-17-5p/miR-130b-3p/PTEN/HIF-1α pathway
Acai Berry 📋✍⛔36904206Oral Treatment with the Extract of Euterpe oleracea Mart. Improves Motor Dysfunction and Reduces Brain Injury in Rats Subjected to Ischemic Stroke
Almond 📋 ⛔34832965The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells
Berries 📋 35217779Effect of berry-based supplements and foods on cognitive function: a systematic review
Beta-Glucan 📋✍⛔38142848Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice
Beta-Sitosterol 📋✍⛔38461353Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles
Bilberry 📋✍⛔36414183Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury
Burdock 📋 ⛔38669967Ethanolic extract of Arctium lappa leaves alleviates cerebral ischemia reperfusion-induced inflammatory injury via HDAC9-mediated NF-κB pathway
Calcium 📋✍⛔35816459Calcium and magnesium in drinking water and risk of myocardial infarction and stroke - a population-based cohort study
Coconut 📋 ⛔29188860A Keto-Mediet Approach with Coconut Substitution and Exercise May Delay the Onset of Alzheimer's Disease among Middle-Aged
Coptis Chinensis 📋 ⛔38306514A network pharmacology method explores the molecular mechanism of Coptis chinensis for the treatment of Alzheimer's disease
Cordyceps 📋✍⛔36521708Cordyceps militaris acidic polysaccharides improve learning and memory impairment in mice with exercise fatigue through the PI3K/NRF2/HO-1 signalling pathway
Coriander Essential Oil 📋✍⛔37627529Direct Evidence for Using Coriandrum sativum var. microcarpum Essential Oil to Ameliorate Scopolamine-Induced Memory Impairment and Brain Oxidative Stress in the Zebrafish Model
Creatine 📋✍⛔38542677The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial
Cryptotanshinone 📋 38071213Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells
Cyanidin 📋✍ 38705400Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling
Dandelion 📋✍⛔35053874Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo
Dioscin 📋 38518642Dioscin decreases M2 polarization via inhibiting a positive feedback loop between RBM47 and NF-κB in glioma
Diosmetin 📋 38460078Diosmetin Ameliorates HFD-induced Cognitive Impairments via Inhibiting Metabolic Disorders, Mitochondrial Dysfunction and Neuroinflammation in Male SD Rats
Essential Oils 📋 ⛔37899272Essential Oils as an Alternative Treatment for Migraine Headache: A Systematic Review and Meta-Analysis
Fermented Foods 📋 ⛔38280441Probiotic, prebiotic, synbiotic and fermented food supplementation in psychiatric disorders: A systematic review of clinical trials
Giloy 📋✍⛔38176666Protective effects of Tinospora cordifolia miers extract against hepatic and neurobehavioral deficits in thioacetamide-induced hepatic encephalopathy in rats via modulating hyperammonemia and glial cell activation
Indian Mulberry 📋✍⛔36765376Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy
Isoliquiritigenin 📋 38395608Isoliquiritigenin attenuates neuroinflammation after subarachnoid hemorrhage through inhibition of NF-κB-mediated NLRP3 inflammasome activation
Lavender 📋✍⛔38078339Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats
Licochalcones 📋 37762479Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment
Magnolia 📋✍⛔32560413Novel Therapeutic Approach for the Management of Mood Disorders: In Vivo and In Vitro Effect of a Combination of L-Theanine, Melissa officinalis L. and Magnolia officinalis Rehder & E.H. Wilson
Oats 📋 ⛔36657906Effect of Avena sativa (Oats) on cognitive function: A systematic review of randomized controlled trials
Olive Polyphenols 📋 36364796Neuroprotective Panel of Olive Polyphenols: Mechanisms of Action, Anti-Demyelination, and Anti-Stroke Properties
Polydatin 📋✍ 36915795Effects of polydatin from Huhuang Shaoshang Liniment on oxidative damage and inflammatory response in rats with cerebral ischemia-reperfusion
Red Yeast Rice 📋✍⛔36917811Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways
Safflower 📋✍⛔38036060Uncovering Mechanism and Efficacy of Salvia Miltiorrhiza-Safflower in Cerebral Ischemia-Reperfusion Injury
Sea Buckthorn 📋✍⛔37485660Flavonoids from Seabuckthorn ( Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice
Syringic Acid 📋 35570553Syringic acid suppressed proliferation, invasion, and migration via inhibition of matrix metalloproteinases expression on glioblastoma cells by promoting apoptosis
Vitamin K2 mk-7 📋✍ 37477796Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
Withanolides 📋 35159267Effect of Withanolide A on 7-Ketocholesterol Induced Cytotoxicity in hCMEC/D3 Brain Endothelial Cells
Aloe Vera 📋✍⛔35292934Aloe vera and Fermented Extracts Exhibit an Anti-Inflammatory Effect on Human Glioblastoma/Astrocytoma U373 MG Cells
Andrographis 📋✍⛔38057817Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway
Anthocyanidins 📋 37474898Association between dietary anthocyanidins intake and depression among US adults: a cross-sectional study (NHANES, 2007-2010 and 2017-2018)
Apple Polyphenols 📋 ⛔38406886Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut-brain axis
Astragalin 📋 36681681Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice
Atractylodes 📋✍⛔38178130Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke
Boric Acid 📋✍⛔37906374Boric acid Increases Susceptibility to Chemotherapy by Targeting the Ferritinophagy Signaling Pathway in TMZ Resistant Glioblastoma Cells
Chamomile 📋✍⛔36302045Ameliorative effects of half-dose saffron and chamomile combination on Psycho-endocrinological changes in a diabetic murine model
Date 📋 ⛔36654869Effects of Phoenix dactylifera against Streptozotocin-Aluminium Chloride Induced Alzheimer's Rats and Their In Silico Study
Flaxseed Oil 📋✍⛔37960203Flaxseed Oil ( Linum usitatissimum) Prevents Cognitive and Motor Damage in Rats with Hyperammonemia
GABA 📋✍⛔38321713GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial
Hypericin 📋 37734259Novel antidepressant mechanism of hypericin: Role of connexin 43-based gap junctions
Krill Oil 📋✍⛔37937381Long-Term Krill Oil Administration Alleviated Early Mild Cognitive Impairment in APP/PS1 Mice
L-Glutamine 📋✍⛔38489176Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease
L-Leucine 📋✍⛔37891741Leucine Reduced Blood-Brain Barrier Disruption and Infarct Size in Early Cerebral Ischemia-Reperfusion
Linoleic Acid 📋✍⛔34111468Protective effect of alpha-linoleic acid on Aβ-induced oxidative stress, neuroinflammation, and memory impairment by alteration of α7 nAChR and NMDAR gene expression in the hippocampus of rats
Modified Citrus Pectin 📋✍⛔35706530Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-ĸB Signaling Pathway in Microglia
Nattokinase 📋✍⛔37466380Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin
Nootkatone 📋 36401752Nootkatone Improves Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors by Repressing NF-κB/NLRP3-Mediated Neuroinflammation
Nutmeg 📋✍⛔35662922Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease
Oleanolic Acid 📋 37812895Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice
Parthenolide 📋 37992573Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway
Peanut 📋 ⛔35418581Peanut (Arachis hypogaea) sprout prevents high-fat diet-induced cognitive impairment by improving mitochondrial function
Pelargonidin 📋 36226369Pelargonidin inhibits vascularization and metastasis of brain gliomas by blocking the PI3K/AKT/mTOR pathway
Phytoestrogens 📋 ⛔37159774Role of Phytoestrogen in Menopausal Women With Depressive Symptoms: A Consecutive Case Series Study
Rehmannia 📋✍⛔35784741Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer's Disease
Retinoic Acid 📋 37149281Retinoic acid has neuroprotective effects by modulating thioredoxin in ischemic brain damage and glutamate-exposed neurons
Safranal 📋 38234630Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1
Sesamin 📋✍ 36847969Effects of sesamin on Aβ1-42-induced oxidative stress and LTP impairment in a rat model of Alzheimer's disease
Tea Polyphenols 📋 38286317Targeting ERS-mitophagy in hippocampal neurons to explore the improvement of memory by tea polyphenols in aged type 2 diabetic rats
Trans-Resveratrol 📋 35799401Neuroprotection by Trans-Resveratrol in Rats With Intracerebral Hemorrhage: Insights into the Role of Adenosine A1 Receptors
Vitamin K2 📋✍⛔34199021Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment
Vitamins 📋 38397800A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation
Apple Vinegar 📋✍⛔34323669Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD
Asafoetida 📋✍⛔38520834Kellerin alleviates cerebral ischemic injury by inhibiting ferroptosis via targeting Akt-mediated transcriptional activation of Nrf2
Bay Leaf 📋 ⛔37689325Neuroprotective and anti-amnesic effects of Laurus Nobilis essential oil against scopolamine-induced memory deficits in mice brain
Beets 📋✍⛔37875637Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial
Black Tea 📋✍⛔34795745Effects of black tea consumption and caffeine intake on depression risk in black tea consumers
Blackcurrant 📋✍⛔38716086Effects of a Flavonoid-Rich Blackcurrant Beverage on Markers of the Gut-Brain Axis in Healthy Females: Secondary Findings From a 4-Week Randomized Crossover Control Trial
Butyrate 📋 ⛔38532150Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach
Carnosol 📋 36775042Carnosol inhibits cerebral ischemia-reperfusion injury by promoting AMPK activation
Cat's Claw 📋✍⛔33589649In vitro comparison of major memory-support dietary supplements for their effectiveness in reduction/inhibition of beta-amyloid protein fibrils and tau protein tangles: key primary targets for memory loss
Chlorella 📋✍⛔37144207Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease
Chrysanthemum 📋✍⛔36567616Neuroprotective effects of Chrysanthemum morifolium on cerebral ischemia- reperfusion injury contributes to the oxidative stress suppression and related Keap1/Nrf2 pathway
Coriander 📋 ⛔37513187Coriandrum sativum and Its Utility in Psychiatric Disorders
Coumaric acid 📋 37414223p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model
Eleuthero 📋✍⛔38545117Acanthopanax senticosus improves cognitive impairment in Alzheimer's disease by promoting the phosphorylation of the MAPK signaling pathway
Feverfew 📋✍⛔38204302Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study
Fiber 📋✍⛔37196565The relationship between dietary fibre and stroke: A meta-analysis
Fruits 📋 38347678Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study
Genipin 📋 37865990Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease
Glucosamine 📋✍⛔38673797Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production
Honey 📋✍⛔37570596Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Horny Goat Weed 📋✍⛔37237865Epimedium Aqueous Extract Ameliorates Cerebral Ischemia/Reperfusion Injury through Inhibiting ROS/NLRP3-Mediated Pyroptosis
Inulin 📋✍⛔35611116Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase
Isorhamnetin 📋 37754268Unraveling the Potential of Isorhamnetin as an Adjuvant in Depression Treatment with Escitalopram
Jujube 📋 ⛔38562322Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models
L-Lysine 📋✍⛔27031721A Nutrient Mixture Inhibits Glioblastoma Xenograft U-87 MG Growth in Male Nude Mice
Lactobacillus plantarum 📋 ⛔33245015Lactobacillus plantarum DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways
Liquiritigenin 📋 33965487Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease
Long Pepper 📋 ⛔37821784The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction
Maitake Mushrooms 📋 ⛔32450016A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice
Omega-6 Fatty Acids 📋✍⛔37971997Association between the intake of dietary n3 and n6 fatty acids and stroke in US adults: A cross-sectional study of NHANES 2007-2018
Orange 📋 ⛔36678510Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease
Orange Essential Oil 📋✍⛔33463729Effects of diffused essential oils for reducing stress and improving mood for clinical nurses: An interventional time series study
Oregano Essential Oil 📋✍⛔35201555A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats
Phosphatidylserine 📋✍⛔33163896Effects of a Nutritional Formulation Containing Caprylic and Capric Acid, Phosphatidylserine, and Docosahexaenoic Acid in Streptozotocin-Lesioned Rats
Procyanidins 📋 ⛔37110816Procyanidins Alleviated Cerebral Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the Nrf2/HO-1 Signaling Pathway
Quercitrin 📋 36292931The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway
Royal Jelly 📋✍⛔38657030Comparative neuroprotective effects of royal jelly and its unique compound 10-hydroxy-2-decenoic acid on ischemia-induced inflammatory, apoptotic, epigenetic and genotoxic changes in a rat model of ischemic stroke
Sage Essential Oil 📋 ⛔32549250Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice
Shilajit 📋✍⛔37846531Investigation of Neuroprotective Effect of Shilajit Extract in Experimental Head Trauma Model Created in Rats
Shogaol 📋 350366856-Shogaol Attenuates Traumatic Brain Injury-Induced Anxiety/Depression-like Behavior via Inhibition of Oxidative Stress-Influenced Expressions of Inflammatory Mediators TNF-α, IL-1β, and BDNF: Insight into the Mechanism
Soy 📋✍⛔36117647Soy product consumption and the risk of major depressive disorder in older adults: Evidence from a cohort study
Spearmint 📋 ⛔30802720The attention-enhancing effects of spearmint extract supplementation in healthy men and women: a randomized, double-blind, placebo-controlled, parallel trial
Telmisartan 📋 ⛔37355897Telmisartan Alleviates Alzheimer's Disease-Related Neuropathologies and Cognitive Impairments
Vitamin B5 📋✍⛔32416962Cerebral Deficiency of Vitamin B5 (D-Pantothenic Acid; Pantothenate) as a Potentially-Reversible Cause of Neurodegeneration and Dementia in Sporadic Alzheimer's Disease
Aloin 📋 33099296Inhibition of NOX2 contributes to the therapeutic effect of aloin on traumatic brain injury
Apple 📋 ⛔35167638Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression- and anxiety-like behavior in mice by abating oxidative stress, inflammation and apoptosis via the miR-22-3p/SIRT1 axis
Arachidonic Acid 📋✍⛔36904193Association between Arachidonic Acid and the Risk of Schizophrenia: A Cross-National Study and Mendelian Randomization Analysis
Asparagus 📋 ⛔34492320Qisheng Wan formula ameliorates cognitive impairment of Alzheimer's disease rat via inflammation inhibition and intestinal microbiota regulation
Basil Essential Oil 📋✍⛔32155616The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study
Beta-Alanine 📋✍⛔37758316Biochemical Mechanisms of Beneficial Effects of Beta-Alanine Supplements on Cognition
Bitter Orange 📋✍⛔38078339Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats
Boron 📋✍⛔34293392Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies
Bromelain 📋✍⛔37076960Effect of Bromelain on Chronic Unpredictable Stress-induced Behavioral, Biochemical, and Monoamine Changes in Wistar Albino Rat Model of Depression
Cardamom 📋✍⛔36781058Cardamom oil ameliorates behavioral and neuropathological disorders in a rat model of depression induced by reserpine
Cheese 📋 ⛔38694223Association between cheese and fish consumption and the occurrence of depression based on European population: mediating role of metabolites
Cherry 📋 ⛔36181653Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop
Cinnamic Acid 📋 35325888Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice
Clove 📋 ⛔37851769Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat
Copper 📋✍⛔36195639Brain copper may protect from cognitive decline and Alzheimer's disease pathology: a community-based study
Cranberry 📋✍⛔35662954Chronic Consumption of Cranberries ( Vaccinium macrocarpon) for 12 Weeks Improves Episodic Memory and Regional Brain Perfusion in Healthy Older Adults: A Randomised, Placebo-Controlled, Parallel-Groups Feasibility Study
Echinacea 📋✍⛔29215298Echinacea Purpurea Protects Against Restraint Stress-Induced Immunosuppression in BALB/c Mice
Equol 📋✍⛔34157864Roles of Phytoestrogen in the Pathophysiology of Intracranial Aneurysm
Eucalyptol 📋 35028340Baiap3 regulates depressive behaviors in mice via attenuating dense core vesicle trafficking in subsets of prefrontal cortex neurons
Eucommia 📋✍⛔35754707Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer's Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter
Isoquercitrin 📋 37391332Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress
L-Citrulline 📋✍⛔33940559Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease
Lemon Essential Oil 📋✍⛔33723134In vitro cytotoxicity of cardamom oil, lemon oil, and jasmine oil on human skin, gastric, and brain cancer cell line
Lingonberry 📋 ⛔26738388[Effects of lingonberry extraction on the mice cognitive function damaged by chronic stress]
Lychee 📋 ⛔31917277Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway
Malvidin 📋 36699054Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice
Matcha Tea 📋 36771286Matcha Tea Powder's Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress
Myrtle 📋✍⛔33475094Myrtus communis improves cognitive impairment in renovascular hypertensive rats
NAD 📋 35956406Supplementation with NAD + and Its Precursors to Prevent Cognitive Decline across Disease Contexts
Neohesperidin 📋 33581209Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics
Nuciferine 📋 38232541Nuciferine reduces inflammation induced by cerebral ischemia-reperfusion injury through the PI3K/Akt/NF-κB pathway
Oleic Acid 📋 ⛔34040528Combined Oral and Topical Application of Pumpkin ( Cucurbita pepo L.) Alleviates Contact Dermatitis Associated With Depression Through Downregulation Pro-Inflammatory Cytokines
Oolong Tea 📋 ⛔35629970Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice
Pau d'Arco 📋✍⛔24236576NMDA receptors and the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway are implicated in the antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice
Perilla 📋✍ 37355083Antidepressant effect of Perilla frutescens essential oil through monoamine neurotransmitters and BDNF/TrkB signal pathway
Phloretin 📋 36793870Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression-like behaviors in the mPFC
Piperlongumine 📋 37161450Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity
Pomelo 📋 ⛔35571242Pomelo Peel Essential Oil Ameliorates Cerebral Ischemia-Reperfusion Injury through Regulating Redox Homeostasis in Rats and SH-SY5Y Cells
Potassium 📋✍⛔28877896Intake of potassium- and magnesium-enriched salt improves functional outcome after stroke: a randomized, multicenter, double-blind controlled trial
Rhubarb 📋 ⛔38668344The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways
Saw Palmetto 📋✍⛔26788112Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell
Star Fuit 📋 ⛔30196278Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease
Theaflavins 📋✍ 31638230Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA‑128‑3p‑mediated Nrf2 inhibition and reducing oxidative stress
Thyme Essential Oil 📋 ⛔38688382Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
Vitamin K 📋✍⛔37032783Association between vitamin K intake and depressive symptoms in US adults: Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2018
Vitamin K2 mk-4 📋✍ 38727984Menaquinone-4 Alleviates Neurological Deficits Associated with Intracerebral Hemorrhage by Preserving Corticospinal Tract in Mice
Yam 📋 35777608Study on the pharmacodynamic effect of Rhizoma Dioscoreae polysaccharides on cerebral ischemia-reperfusion injury in rats and the possible mechanism
Alpha GPC 📋✍⛔38595916Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease
Anethole 📋 36986541Anethole Pretreatment Modulates Cerebral Ischemia/Reperfusion: The Role of JNK, p38, MMP-2 and MMP-9 Pathways
Barley 📋✍⛔36087390Effect of aqueous extract of barley and wheat grass in stress induced depression in Swiss mice
Bergamot 📋✍⛔28591067Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia: Data From an 8-Week, Open-Label Pilot Study
Beta-Cryptoxanthin 📋 32435993Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor development in offspring at 2 years of age
Betulinic Acid 📋 38396785Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
Bitter Melon 📋✍⛔36902074The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease
Black Pepper Essential Oil 📋 ⛔33997409Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum Linn. (Black pepper) in mice: involvement of serotonergic but not GABAergic transmission system
Camellia 📋 ⛔35699196Protective effects of camellia and olive oils against cognitive impairment via gut microbiota-brain communication in rats
Cardamonin 📋 36672126The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer's Disease
Casein Protein 📋✍⛔36245498The anti-anxiety/depression effect of a combined complex of casein hydrolysate and γ-aminobutyric acid on C57BL/6 mice
Cashew 📋 ⛔38002521Cashew ( Anacardium occidentale) Extract: Possible Effects on Hypothalamic-Pituitary-Adrenal (HPA) Axis in Modulating Chronic Stress
Chaga Mushrooms 📋✍⛔38053824Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system
Chicoric Acid 📋 38542381Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models
Chondroitin 📋✍⛔35923649Risk of ischaemic stroke among new users of glucosamine and chondroitin sulphate: a nested case-control study
Cinnamon Essential Oil 📋✍⛔35359846Metabonomics Study in Mice With Learning and Memory Impairment on the Intervention of Essential Oil Extracted From Cinnamomum camphora Chvar. Borneol
Citral 📋 29501481Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule
Clove Essential Oil 📋 ⛔37119836Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease
Conjugated Linoleic Acid 📋✍⛔36028179Conjugated linoleic acid downregulates Alzheimer's hallmarks in aluminum mouse model through an Nrf2-mediated adaptive response and increases brain glucose transporter levels
Corn Silk 📋✍⛔37563784Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation
D-Limonene 📋✍⛔33564342Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress
D-Mannose 📋✍⛔35490896Mannose inhibits proliferation and promotes apoptosis to enhance sensitivity of glioma cells to temozolomide through Wnt/β-catenin signaling pathway
Diallyl Disulfide 📋 33511484Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress
DIM 📋✍⛔354618193,3'-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice
Egg 📋 ⛔37340479Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study
Elderberry 📋✍⛔38673938Feasibility and Preliminary Efficacy of American Elderberry Juice for Improving Cognition and Inflammation in Patients with Mild Cognitive Impairment
Essential Amino Acids 📋✍⛔37397466A balanced formula of essential amino acids promotes brain mitochondrial biogenesis and protects neurons from ischemic insult
Essential Fatty Acids 📋✍ 32917237Important considerations when assessing the effect of essential fatty acids on cognitive performance
Eucalyptus 📋✍⛔35298858Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial
Evening Primrose Oil 📋✍⛔32522946Fish Oil and Primrose Oil Suppress the Progression of Alzheimer's Like Disease Induced by Aluminum in Rats
Fat 📋 36986159Dietary Fats and Cognitive Status in Italian Middle-Old Adults
Fig 📋 ⛔25212824Ficus carica latex prevents invasion through induction of let-7d expression in GBM cell lines
Frankincense Essential Oil 📋 ⛔31582666The Effects of Frankincense Essential Oil on Stress in Rats
Garlic Oil 📋 ⛔37435927Garlic essential oil ameliorates depression-like behaviors in unpredictable chronic mild stress by modulating the brain NLRP3 inflammasome pathway and influencing the gut barrier and microbiota
Geranium Essential Oil 📋 ⛔31490773Oral supplementation with geranium oil or anise oil ameliorates depressed rat-related symptoms through oils antioxidant effects
Ginkgolic Acid 📋 36396110CCL2-targeted ginkgolic acid exerts anti-glioblastoma effects by inhibiting the JAK3-STAT1/PI3K-AKT signaling pathway
Grape Seed Oil 📋 ⛔32665902Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases
Hazelnut 📋 ⛔29208493Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents
Helichrysum 📋 ⛔37570911Phytochemical Profiling, Antioxidant and Cognitive-Enhancing Effect of Helichrysum italicum ssp. italicum (Roth) G. Don (Asteraceae)
HMB 📋✍⛔37437568Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice
Iron 📋✍⛔25837213Dietary intake of minerals in relation to depressive symptoms in Japanese employees: the Furukawa Nutrition and Health Study
L-Alanine 📋✍⛔33626855Extremely Low Serum Alanine Transaminase Level Is Associated with All-Cause Mortality in the Elderly after Intracranial Hemorrhage
L-Histidine 📋✍⛔34836128Deficiency in the Essential Amino Acids l-Isoleucine, l-Leucine and l-Histidine and Clinical Measures as Predictors of Moderate Depression in Elderly Women: A Discriminant Analysis Study
Lauric Acid 📋✍ 37572940Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke
Lemon Verbena 📋 ⛔35011093Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract
Loquat 📋✍⛔37513484Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice
Lupeol 📋 37447385A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer's Disease
Mango 📋 ⛔35344129Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis
Mango Leaf 📋 ⛔32717999Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study
Marjoram Essential Oil 📋 ⛔38045619Inhalation of Origanum majorana L. essential oil while working reduces perceived stress and anxiety levels of nurses in a COVID-19 intensive care unit: a randomized controlled trial
Milk 📋 ⛔36046132Milk intake enhances cerebral antioxidant (glutathione) concentration in older adults: A randomized controlled intervention study
Minerals 📋 37108261Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression
Morusin 📋 26829656Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells
Myrrh 📋✍⛔36280019Guggulsterone from Commiphora mukul potentiates anti-glioblastoma efficacy of temozolomide in vitro and in vivo via down-regulating EGFR/PI3K/Akt signaling and NF-κB activation
Okra 📋 ⛔38060590Protective and therapeutic effects of okra seed in acute nontraumatic brain injury
Omega-9 Fatty Acids 📋 34666393Selective Toxicity Effect of Fatty Acids Omega-3, 6 and 9 Combination on Glioblastoma Neurons through their Mitochondria
Onion 📋✍⛔38688382Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
Papaya 📋✍⛔37626269Phytochemical Extract from Carica papaya Leaves and Punica granatum Seeds as Therapy Against Cognitive Impairment in a Murine Model
Parsley 📋 ⛔34173678Investigation of possible neuroprotective effects of some plant extracts on brain in bile duct ligated rats
Pear 📋 ⛔34602398Determination of anxiolytic and antidepressant like activity of hydro alcoholic fruit extract of Pyrus communis (L.) and its impact on the memory after chronic dosing in animal models
Phellodendron 📋✍⛔18426577Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial
Pine Needle Essential Oil 📋✍⛔33655878Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus
Pine Nut 📋 ⛔37821052Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
Pistachio 📋✍⛔35075081Chronically Pre-treatment of Pistachio Alters the Morphology of CA1 Hippocampus Neurons Following Transient Focal Cerebral Ischemia in Male Wistar Rats
Plum 📋 ⛔30577585Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential Oils as Antioxidant and of Cholinesterases Inhibitors
Protein 📋✍⛔38674911Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60
Pumpkin 📋 ⛔34336111L. Cucurbita pepo Alleviates Chronic Unpredictable Mild Stress via Modulation of Apoptosis, Neurogenesis, and Gliosis in Rat Hippocampus
Raspberry 📋✍⛔31328696Red raspberry ( Rubus ideaus) supplementation mitigates the effects of a high-fat diet on brain and behavior in mice
Rosavin 📋 ⛔37758932Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model
Rose 📋 37078068Effect of Rosa damascena Extract on Rat Model Alzheimer's Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study
Rose Essential Oil 📋 38688895A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats
Rosehip 📋✍⛔37088237Rosa canina L. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats
Seaweeds 📋 ⛔37405739Neuroprotective Potential of Brown Seaweed Phytochemicals in Rodent Models of Cerebral Ischemia
Serrapeptase 📋✍⛔35694981The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach
Sesame Oil 📋 ⛔33049345Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways
Soy Protein 📋✍⛔36561237Ameliorating Effect of Standardized Extract From Textured Soy Protein ( Glycine max L.) on Memory Deficit and Learning Insufficiency in Scopolamine-induced Amnesia
Spices 📋 34279199Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease
Sweet Potato 📋 ⛔35720655Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction
Theobromine 📋✍⛔31010016Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats
Thyme 📋✍⛔38039009Effects of orally administered Thymus vulgaris leaves on memory, anxiety, depression, and sleep quality in university students: a randomized controlled trial
Tongkat Ali 📋✍⛔30574050Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study
Turkey Tail Mushrooms 📋 ⛔36208821Coriolus versicolor and its bioactive molecule are potential immunomodulators against cancer cell metastasis via inactivation of MAPK pathway
UDCA 📋✍⛔37989444Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO
Vegetables 📋 35307760Associations of specific types of fruit and vegetables with perceived stress in adults: the AusDiab study
Vitamin B7 📋✍⛔33171595PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression-A Randomized Controlled Trial
Whey Protein 📋✍⛔38137233Protective Effects of Whey Protein Hydrolysate, Treadmill Exercise, and Their Combination against Scopolamine-Induced Cognitive Deficit in Mice
White Mushrooms 📋 ⛔36291298White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease
Yiang Yiang Essential Oil 📋 ⛔17211115[The effects of the inhalation method using essential oils on blood pressure and stress responses of clients with essential hypertension]
Apricot 📋 ⛔31550185Trans-Himalayan Phytococktail Confers Protection Against Hypobaric Hypoxia-Induced Hippocampal Neurodegeneration and Memory Impairment in Male Sprague Dawley Rats
Arctiin 📋 32609480Antidepressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- and TNF-α/TNFR1-Mediated NF-κB Activation
Arjuna 📋✍⛔36234986Neuroprotective Effect of Polyphenol Extracts from Terminalia chebula Retz. against Cerebral Ischemia-Reperfusion Injury
Avocado Oil 📋 ⛔26180820Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats
Bamboo 📋✍⛔38334213The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model
Barberry 📋✍⛔36186093Neuroprotective Effect of Root Extracts of Berberis Vulgaris (Barberry) on Oxidative Stress on SH-SY5Y Cells
Black Ginger 📋✍⛔36904098Kaempferia parviflora Extracts Protect Neural Stem Cells from Amyloid Peptide-Mediated Inflammation in Co-Culture Model with Microglia
Blackberry 📋 ⛔38430352Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling
Brazil Nut 📋 ⛔25567069Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial
Bread 📋 38528644Sourdough bread as nutritional intervention tool for improvement of cognitive dysfunction in diabetic rats
Broccoli 📋 ⛔37839110The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model
Camphor Essential Oil 📋 ⛔38621882[Essential oil of Cinnamomum camphora mitigates depression-like behavior in mice by regulating Nrf2/HO-1 pathway and inhibiting inflammatory cytokines]
Carrot 📋 ⛔16755009Pharmacological evidence for the potential of Daucus carota in the management of cognitive dysfunctions
Cedarwood Essential Oil 📋✍⛔32037737Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia
Celery 📋 ⛔36334223Beneficial effects of celery seed extract (Apium graveolens), as a supplement, on anxiety and depression in hypertensive patients: a randomized clinical trial
Chebulinic Acid 📋 37453379Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses
Citrus Fruits 📋 ⛔34266770Poncirin ameliorates oxygen glucose deprivation/reperfusion injury in cortical neurons via inhibiting NOX4-mediated NLRP3 inflammasome activation
Cornus 📋 34689137Loganin substantially ameliorates molecular deficits, pathologies and cognitive impairment in a mouse model of Alzheimer's disease
Dairy 📋 35947163Associations between total dairy, high-fat dairy and low-fat dairy intake, and depressive symptoms: findings from a population-based cross-sectional study
Diallyl Trisulfide 📋 35921994Diallyl trisulfide sensitizes radiation therapy on glioblastoma through directly targeting thioredoxin 1
Docosapentaenoic Acid 📋✍ 33178186The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models
Eclipta Alba 📋✍ 38562322Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models
Eggplant 📋 ⛔34994925Effect of Solanum vegetables on memory index, redox status, and expressions of critical neural genes in Drosophila melanogaster model of memory impairment
Fennel 📋✍⛔32491286Protective effect of fennel, and its major component trans-anethole against social isolation induced behavioral deficits in rats
Fir Needle Oil 📋 ⛔36429972Relaxing Effects of Breathing Pseudotsuga menziesii and Lavandula angustifolia Essential Oils on Psychophysiological Status in Older Adults
Fufang Danshen 📋 29770796Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease
Gamma-Linolenic Acid 📋✍⛔32439412GAMMA-LINOLENIC ACID ALTERS MIGRATION, PROLIFERATION AND APOPTOSIS IN HUMAN AND RAT GLIOBLASTOMA CELLS
Geraniin 📋 35222793Geraniin Protects against Cerebral Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Neuronal Apoptosis via Regulation of the Nrf2/HO-1 Pathway
Ginger Essential Oil 📋✍ 19285110Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice
Glutathione 📋✍⛔35310529Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease
Grapefruit 📋 ⛔36500599Recovery of Naringin-Rich Flavonoid Extracts from Agroresidues with Anxiolytic- and Antidepressant-like Effects in Mice
Grapefruit Essential Oil 📋✍⛔33463729Effects of diffused essential oils for reducing stress and improving mood for clinical nurses: An interventional time series study
Grapefruit extract 📋✍⛔37283121Flavonoids from Citrus paradise cv. Changshan-huyou exerts protective effect on ischemia-induced cerebral injury in mice via inhibiting RhoA-ROCK2 signaling pathway
Guava 📋 ⛔36758825Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species
Honeysuckle 📋 ⛔37863440Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice
Hops 📋✍⛔35854340Humulus japonicus attenuates LPS-and scopolamine-induced cognitive impairment in mice
Hyaluronic Acid 📋✍⛔32213158Hyaluronic Acid and Regenerative Medicine: New Insights Into the Stroke Therapy
Hyssop 📋✍⛔35963984The Effects of Methanol Extracts of Hyssopus officinalis on Model of Induced Glioblastoma Multiforme (GBM) in Rats
Iodine 📋✍⛔32802419The Relationship between Iodine and Selenium Levels with Anxiety and Depression in Patients with Euthyroid Nodular Goiter
Isoflavones 📋✍⛔35334883The Inverse Correlation of Isoflavone Dietary Intake and Headache in Peri- and Post-Menopausal Women
Jasmine 📋 ⛔35010973Jasmine Tea Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior in Rats via the Gut-Brain Axis
Jasmine Essential Oil 📋 33723134In vitro cytotoxicity of cardamom oil, lemon oil, and jasmine oil on human skin, gastric, and brain cancer cell line
Kacip Fatimah 📋✍⛔20217640Protective effect of Labisia pumila on stress-induced behavioral, biochemical, and immunological alterations
Kava Root 📋✍⛔11536390Kava and valerian in the treatment of stress-induced insomnia
Kiwifruit 📋✍⛔34831142Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis
Kombucha 📋✍⛔37402035Chronic Kombucha Beverage Consumption Attenuates Inflammatory Markers and Histopathology of Brain Tissue in Transnet Global Brain Ischemia in Rats
L-Proline 📋✍⛔27031721A Nutrient Mixture Inhibits Glioblastoma Xenograft U-87 MG Growth in Male Nude Mice
L-Tyrosine 📋✍⛔10023508A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria
Laminaria 📋✍⛔35394414Polysaccharides from laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation
Lecithin 📋✍⛔37009142Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination
Lemon Balm Essential Oil 📋✍⛔24745610Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells
Lemongrass 📋✍⛔28499312Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice
Lemongrass Essential Oil 📋✍⛔29501481Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule
Lettuce 📋 ⛔35101010In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa
Limonin 📋 25864108A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway
Maca Root 📋✍⛔24931003Maca reduces blood pressure and depression, in a pilot study in postmenopausal women
Madecassoside 📋 32721993Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Centella asiatica
Manganese 📋✍⛔35369103Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies
Marigold 📋✍⛔26120230Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats
Marjoram 📋 ⛔33266220Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice
Milk Thistle 📋✍⛔28842342Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice
MSM 📋✍⛔35203043Methylsulfonylmethane protects against ethanol-induced brain injury in mice through the inhibition of oxidative stress, proinflammatory mediators and apoptotic cell death
Mucuna Pruriens 📋✍⛔36875022Effect of Mucuna pruriens on brain NMDA receptor and tau protein gene expression in cerebral ischemic rats
Neem 📋✍ 35198760Anxiolytic and antidepressant-like activities of aqueous extract of Azadirachta indica A. Juss. flower in the stressed rats
Nimbolide 📋 38036978In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma
Nitrate 📋✍⛔37331149Habitual dietary nitrate intake and cognition in the Australian Imaging, Biomarkers and Lifestyle Study of ageing: A prospective cohort study
Noni 📋 ⛔36118093Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice
Oak Gall 📋✍⛔34961052Gallotannin-Enriched Fraction from Quercus infectoria Galls as an Antioxidant and Inhibitory Agent against Human Glioblastoma Multiforme
Olive 📋✍⛔34796529Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke-induced depressive-like behaviors in Sprague-Dawley rats
Oregano 📋✍⛔36284120Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy
Pantethine 📋✍⛔37194410Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species
Peach 📋 ⛔35598297Single-cell Transcriptomic Analysis Demonstrates the Regulation of Peach Polysaccharides on Circadian Rhythm Disturbance
Postbiotics 📋 37934614Gut microbiome-targeted therapies for Alzheimer's disease
Proanthocyanidins 📋 23523627Identification of oligomer proanthocyanidins (F2) isolated from grape seeds as a formyl peptide receptor 1 partial agonist
Prunella Vulgaris 📋✍⛔35678758Vulgarisin-type diterpenoids from self-heal ( Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway
Psyllium 📋✍⛔31103857Intake of Psyllium Seed Husk Reduces White Matter Damage in a Rat Model of Chronic Cerebral Hypoperfusion
Pu-erh Tea 📋✍⛔32992081Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation
Pueraria Mirifica 📋✍⛔26915634Neurotherapeutic Effects of Pueraria Mirifica Extract in Early- And Late-Stage Cognitive Impaired Rats
Pumpkin Seed 📋✍⛔37006627Cucurbita maxima Seeds Reduce Anxiety and Depression and Improve Memory
Pyridoxal-5-Phosphate 📋✍⛔30692033B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study
Quinoa 📋 ⛔34678977Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells
Salt 📋 ⛔35788204Role of no table salt on hypertension and stroke based on large sample size from National Health and Nutrition Examination Survey database
Scutellarein 📋 37239029A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease
Sea Cucumber 📋 38369274Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification
Seafood 📋 36354985Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect
Shiitake Mushrooms 📋✍⛔33541370β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis
Sirtuin Activators 📋 35487384Sirtuin 1 alleviates microglia-induced inflammation by modulating the PGC-1α/Nrf2 pathway after traumatic brain injury in male rats
Sorghum 📋 ⛔34690742Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article
Spearmint Essential Oil 📋✍⛔31772594Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections
Spinach 📋 ⛔10479711Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits With Blueberry, Spinach, or Strawberry Dietary Supplementation
Sunflower Oil 📋✍⛔33749789Systemic administration of sunflower oil exerts neuroprotection in a mouse model of transient focal cerebral ischaemia
Tamarind 📋 ⛔35481086The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches
Tangerine 📋 ⛔35100035Effects of Citrus depressa Hayata Fruit Extract on Thigh Muscles Mass and Composition in Subacute Stroke Patients: A Double-Blind, Randomized, Controlled Pilot Trial
Tea Tree Essential Oil 📋 ⛔33468026Natural substances to potentiate canonical glioblastoma chemotherapy
Theabrownins 📋 33995088Theabrownin Induces Cell Apoptosis and Cell Cycle Arrest of Oligodendroglioma and Astrocytoma in Different Pathways
Tomato 📋 ⛔25613481Tomato thymidine kinase-based suicide gene therapy for malignant glioma--an alternative for Herpes Simplex virus-1 thymidine kinase
Vitamin B8 📋✍⛔36339275A Randomized, Double-Blind, Controlled Clinical Trial of Omega-3 Fatty Acids and Inositol as Monotherapies and in Combination for the Treatment of Pediatric Bipolar Spectrum Disorder in Children Age 5-12
Vitamin K1 📋✍⛔35660920Inverse association between plasma phylloquinone and risk of ischemic stroke in Chinese adults with hypertension and high body mass index: a nested case-control study
Wasabi 📋 ⛔37960261Benefits of Wasabi Supplements with 6-MSITC (6-Methylsulfinyl Hexyl Isothiocyanate) on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial
Wine 📋 ⛔26092624Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer's Disease
Xylitol 📋✍⛔36154609Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice
Yohimbine 📋✍ 34889886Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments
Zingerone 📋 35639359Protective Effects of Zingerone Against Depression-Like Behavior and Biochemical Changes in Chronic Stressed Rats: Antioxidant Effects