| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Curcumin | 📋 | ✍ | ⛔ | | 40573993 | Curcumin-Induced Apoptotic Cell Death in Human Glioma Cells Is Enhanced by Clusterin Deficiency |
| Melatonin | 📋 | ✍ | ⛔ | | 40563356 | The Interplay Between Melatonin and Nitric Oxide: Mechanisms and Implications in Stroke Pathophysiology |
| Ginsenosides | 📋 | ✍ | ⛔ | | 40510292 | Ginsenoside C-K inhibits A? oligomer-induced Alzheimer's disease pathology progression by regulating microglia-neuron interactions |
| Resveratrol | 📋 | ✍ | ⛔ | | 40546125 | Protective Effect of Resveratrol Against Intracranial Aneurysm Rupture in Mice |
| Cannabidiol | 📋 | ✍ | ⛔ | | 40558565 | Cannabidiol Effects on Depressive-like Behavior and Neuroinflammation in Female Rats Exposed to High-Fat Diet and Unpredictable Chronic Mild Stress |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 40518806 | Vitamin D and cognition: Demographic disparities in memory recall and word intrusion in a multiethnic cohort |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 40563811 | Sleep Deprivation and Alzheimer's Disease: A Review of the Bidirectional Interactions and Therapeutic Potential of Omega-3 |
| Berberine | 📋 | ✍ | ⛔ | | 40454536 | Anti-neurodegenerative treatment in Alzheimer's disease: Multifaceted mechanisms of action of berberine |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 40449691 | Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 against cognitive impairment |
| Quercetin | 📋 | ✍ | ⛔ | | 40567363 | Neuroprotective potential of quercetin in Alzheimer's disease: targeting oxidative stress, mitochondrial dysfunction, and amyloid-? aggregation |
| Vitamin C | 📋 | ✍ | ⛔ | | 40510983 | A Cross-Sectional Study to Assess the Level of Antioxidant Ascorbic Acid (Vitamin C) in Diagnosed Patients of Depression at Tertiary Care Hospital of Central India |
| Astragalosides | 📋 | ✍ | ⛔ | | 40239538 | Network pharmacology and experimental verification to explore the molecular mechanisms of Astragaloside IV against diabetic encephalopathy |
| EGCG | 📋 | ✍ | ⛔ | | 40172817 | Neuroprotective Effects of Catechins by Differentially Affecting the Binding of Beta-amyloid and Its Aggregates to the Target Cells |
| Citicoline | 📋 | ✍ | ⛔ | | 40255575 | The efficacy of different doses of citicoline in improving the prognosis of patients with acute ischemic stroke based on network meta-analysis |
| Ginkgolides | 📋 | | | | 40522419 | A Cross-sectional In Vitro Study on the Synergistic Neuroprotective Effects of Phytochemicals Ferulic Acid and Ginkgolide B against Amyloid Beta-induced Oxidative Stress and Modulation of Multifunctional Enzyme APE1/Ref-1 in Human Neuroblastoma SH-SY5Y Cells |
| Luteolin | 📋 | ✍ | ⛔ | | 40541584 | Untargeted metabolomics reveals the mechanisms of luteolin and exercise combination treatment against cognitive impairments in AD mice through modulating autophagy |
| Sulforaphane | 📋 | ✍ | ⛔ | | 40227271 | Activation of the Nrf2 Pathway by Sulforaphane Improves Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes |
| Astaxanthin | 📋 | ✍ | ⛔ | | 40582771 | Astaxanthin as an adjunct therapy in Alzheimer's disease and multiple sclerosis: neuroprotective mechanisms and future perspective |
| Ginseng | 📋 | ✍ | ⛔ | | 40453349 | Korean black ginseng extract alleviates Alzheimer's disease-related cognitive impairment by activating the Nrf2/HO-1 pathway and suppressing the p38 MAPK/NF-?B/STAT3 pathways and NLRP3 inflammasome via TLR2 and TLR4 modulation |
| CoQ10 | 📋 | ✍ | ⛔ | | 40507939 | Traumatic Brain Injury and Coenzyme Q10: An Overview |
| Saffron | 📋 | ✍ | ⛔ | | 40414301 | An examination into the effects of a saffron extract (affronŽ) on mood and general wellbeing in adults experiencing low mood: a randomised, double-blind, placebo-controlled trial |
| Salidroside | 📋 | | | | 40542883 | Salidroside Exerts Neuroprotective Effects via Inhibiting Ferroptosis in Mice with Traumatic Brain Injury |
| Magnesium | 📋 | ✍ | ⛔ | | 39275138 | Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 40478359 | The effect of N-acetylcysteine on apoptosis and NGF-Akt/Bad pathway in the hippocampus tissue of cerebral ischemia-reperfusion in male rats |
| Micronutrients | 📋 | | ⛔ | | 40573075 | Effects of Dietary Interventions on Cognitive Outcomes |
| Metformin | 📋 | ✍ | ⛔ | | 40531218 | Genetic insights into the effect of Metformin on psychiatry disorders |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 40316879 | Dual Mechanism of Docosahexaenoic acid (DHA) in Alzheimer's Disease: PAD4 Inhibition and Autophagy Stimulation |
| Crocin | 📋 | ✍ | ⛔ | | 40419073 | Crocin drives intestinal microbiota variation in a rat model of Alzheimer's disease by reducing DKK3 expression |
| Genistein | 📋 | ✍ | ⛔ | | 40124394 | Genistein improves depression-like behavior in rats by regulating intestinal flora and altering glutamate gene expression |
| Puerarin | 📋 | ✍ | ⛔ | | 40505745 | Puerarin mitigates cerebral ischemia/reperfusion (CIR)-induced ferroptosis by suppressing Ser15 phosphorylation-mediated p53 activation |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 40249981 | The effects of methyl nutrients on cognition and one carbon metabolism in older adults with mild cognitive impairment, A systematic review and meta-analysis |
| Apigenin | 📋 | ✍ | ⛔ | | 40124778 | Apigenin protects ischemic stroke by regulating intestinal microbiota homeostasis, regulates brain metabolic profile |
| Ashwagandha | 📋 | ✍ | ⛔ | | 40508211 | Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease |
| Caffeine | 📋 | ✍ | ⛔ | | 40507194 | Caffeine: A Neuroprotectant and Neurotoxin in Traumatic Brain Injury (TBI) |
| Baicalin | 📋 | ✍ | ⛔ | | 40589105 | Baicalin ameliorated neurological damage in animal models of stroke through its antioxidant and anti-apoptotic effects |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 40249981 | The effects of methyl nutrients on cognition and one carbon metabolism in older adults with mild cognitive impairment, A systematic review and meta-analysis |
| Medicinal Plants | 📋 | | | | 40516828 | Traditional Chinese herbal medicines for the treatment of ischemic stroke in China |
| Vitamin E | 📋 | ✍ | ⛔ | | 40562949 | Positive effects of HIIT and vitamin E on cognitive function, angiogenesis and NRF2 antioxidant pathway in male rats with Alzheimer's disease |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 39988721 | Acylcarnitines metabolism in depression: association with diagnostic status, depression severity and symptom profile in the NESDA cohort |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 40484332 | Dietary alpha-lipoic acid prevents depression-like and anxiety-like behavior under aircraft noise exposure in young adult male mice |
| Selenium | 📋 | ✍ | ⛔ | | 40345207 | The Potential Benefits of Chromium and Selenium Supplementation Across Psychiatric Disorders and Symptoms |
| Phytochemicals | 📋 | | | | 40426956 | Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora |
| Food | 📋 | | | | 40573075 | Effects of Dietary Interventions on Cognitive Outcomes |
| Goji Berry | 📋 | ✍ | ⛔ | | 40220965 | Lycium barbarum polysaccharide ameliorates corticosterone-induced cognition decline with modulation of CRHR1 |
| Gotu Kola | 📋 | ✍ | ⛔ | | 40034352 | Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice |
| Schisandra | 📋 | ✍ | ⛔ | | 40471999 | Exploring the Effects of Effective Parts of Schisandra sphenanthera on the Gut-Brain Axis of Type 2 Diabetes Mellitus Rats Based on Metabolomic and Proteomic Approaches |
| Baicalein | 📋 | ✍ | ⛔ | | 40290868 | Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation |
| Hesperidin | 📋 | ✍ | ⛔ | | 40445481 | Neuroprotective Effects of Hesperidin and CK2 Inhibitor DRB on A?1-42-Induced Neurotoxicity in Differentiated SH-SY5Y Cells |
| Salvianolic Acid | 📋 | | | | 40383364 | Salvianolic acid B exerts cerebroprotective effects after traumatic brain injury via Nrf2-dependent antioxidant and anti-inflammatory cascades |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 40373631 | Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition |
| Pterostilbene | 📋 | ✍ | ⛔ | | 40291020 | Pterostilbene: A natural neuroprotective stilbene with anti-Alzheimer's disease properties |
| Thymoquinone | 📋 | | ⛔ | | 40542063 | Thymoquinone controlled obesity and invigorated cognitive and memory performance in rats consuming a high-fat diet via modulating oxidative stress, inflammation and apoptosis |
| Icariin | 📋 | ✍ | | | 40429978 | Icariin Ameliorates Cyclophosphamide-Induced Renal Encephalopathy by Modulating the NF-κB and Keap1-Nrf2 Signaling Pathways |
| Panax Notoginseng | 📋 | ✍ | ⛔ | | 40432445 | Protective Effects of Panax notoginseng Saponins on Cerebral Ischemia/Reperfusion Injury: Insights Into SIRT1/NRF2/HO-1 Pathway Activation |
| Chrysin | 📋 | ✍ | ⛔ | | 39748776 | Therapeutic potential of chrysin in regulation of interleukin-17 signaling in a repeated intranasal amyloid-beta-induced Alzheimer's disease model |
| Naringin | 📋 | ✍ | ⛔ | | 40461204 | [Study on mechanism of naringin in alleviating cerebral ischemia/reperfusion injury based on DRP1/LRRK2/MCU axis] |
| Andrographolide | 📋 | | | | 39266624 | Andrographolide sensitizes glioma to temozolomide by inhibiting DKK1 expression |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 39490923 | Differential impact of eicosapentaenoic acid and docosahexaenoic acid in an animal model of Alzheimer's disease |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 40522419 | A Cross-sectional In Vitro Study on the Synergistic Neuroprotective Effects of Phytochemicals Ferulic Acid and Ginkgolide B against Amyloid Beta-induced Oxidative Stress and Modulation of Multifunctional Enzyme APE1/Ref-1 in Human Neuroblastoma SH-SY5Y Cells |
| Fisetin | 📋 | ✍ | ⛔ | | 40215814 | Single-nucleus RNA sequencing and network pharmacology reveal the mediation of fisetin on neuroinflammation in Alzheimer's disease |
| Naringenin | 📋 | ✍ | ⛔ | | 40486726 | Promising neuroprotective potential of naringenin against trimethyltin-induced cognitive deficits and hippocampal neurodegeneration in rats |
| L-Theanine | 📋 | ✍ | ⛔ | | 40504752 | Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice |
| Nobiletin | 📋 | ✍ | | | 40260073 | Nobiletin alleviates brain injury in uremic mice and inhibits indoxyl sulfate-induced neurotoxicity in HT22 cells through the phosphatidylinositol 3-kinase/protein kinase B signaling pathway |
| Probiotics | 📋 | ✍ | ⛔ | | 40495848 | Gut-brain connection in schizophrenia: A narrative review |
| Rutin | 📋 | ✍ | ⛔ | | 40510902 | Potential of rutin from Rhizophora mucronata leaves as a Inhibitor of Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2 related factor 2 Keap1/Nrf2): An in silico study for Alzheimer's therapy |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 40418429 | Study on the Mechanism of Dihydromyricetin in Alleviating Depressive-Like Behavior in Rats Based on Network Pharmacology |
| Blueberry | 📋 | ✍ | ⛔ | | 39458533 | Addressing Mental Health in Rural Settings: A Narrative Review of Blueberry Supplementation as a Natural Intervention |
| Fish Oil | 📋 | ✍ | ⛔ | | 40564971 | Omega-3 Fatty Acids Mitigate Long-Lasting Disruption of the Endocannabinoid System in the Adult Mouse Hippocampus Following Adolescent Binge Drinking |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 40012817 | The Effects of Aromatherapy With Clove and Lavender on Headache Caused by Spinal Anesthesia in Patients Undergoing Urological Surgery: A Randomized Clinical Trial Study |
| NMN | 📋 | ✍ | ⛔ | | 39422945 | Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 40243772 | Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against Scopolamine-Induced Memory Deficits via Modulation of the cAMP/PKA-CREB-BDNF Pathway |
| Green Tea | 📋 | ✍ | ⛔ | | 40290036 | Effects of Guarana and Green Tea Consumption on Students' Intellectual Performances |
| Lycopene | 📋 | ✍ | ⛔ | | 40378674 | Lycopene alleviates cognitive dysfunctions in an Alzheimer's disease rat model via suppressing the oxidative and neuroinflammatory signaling |
| Paeoniflorin | 📋 | | | | 40427467 | Paeoniflorin Alleviates Lipopolysaccharide-Induced Neuroinflammation and Depression Through the Keap1/Nrf2/HO-1 Signaling Pathway |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 40227285 | Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 40091261 | The anti-inflammatory effects of vitamin B6 on neuroinflammation and neuronal damage caused by 1,2-diacetylbenzene in BV2 microglial and sH-SY5Y cells |
| Geniposide | 📋 | | | | 40257488 | Geniposide protects against cerebral ischemic injury by targeting SOX2/RIPK1 axis |
| Olive Oil | 📋 | ✍ | ⛔ | | 40004234 | Bioactivity and Neuroprotective Effects of Extra Virgin Olive Oil in a Mouse Model of Cerebral Ischemia: An In Vitro and In Vivo Study |
| Piperine | 📋 | ✍ | ⛔ | | 40578941 | Piperine Targets MAOB and Enhances Temozolomide-induced Cytotoxicity in Glioblastoma Cell Lines |
| Cocoa | 📋 | ✍ | ⛔ | | 39397049 | A clinical trial of the effects of cocoa rich chocolate on depression and sleep quality in menopausal women |
| Polyphenols | 📋 | | | | 40440244 | Traumatic brain injury: a review of pathophysiology and therapeutic potential of polyphenols |
| Tanshinone | 📋 | | | | 40542896 | Tanshinone IIA inhibits neuronal ferroptosis and relieves cerebral ischemia?reperfusion injury by regulating miR-449a/ACSL4 |
| Walnut | 📋 | | ⛔ | | 37814808 | Gut microbiome and brain transcriptome analyses reveal the effect of walnut oil in preventing scopolamine-induced cognitive impairment |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 39806460 | Boswellic acid synergizes with low-dose ionizing radiation to mitigate thioacetamide-induced hepatic encephalopathy in rats |
| Gallic Acid | 📋 | | ⛔ | | 40050387 | Gallic acid alleviates ferroptosis by negatively regulating APOC3 and improves nerve function deficit caused by traumatic brain injury |
| Pomegranate | 📋 | | ⛔ | | 39519499 | In Vitro Assessment of the Neuroprotective Effects of Pomegranate (Punica granatum L.) Polyphenols Against Tau Phosphorylation, Neuroinflammation, and Oxidative Stress |
| Irisin | 📋 | | | | 40581647 | Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis |
| Rosmarinic Acid | 📋 | ✍ | | | 40481731 | Rosmarinic acid attenuates photophobia, hyperalgesia and neuroinflammation during nitroglycerine induced migraine like headache in mice |
| Zinc | 📋 | ✍ | ⛔ | | 40491365 | Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease |
| Astragalus Root | 📋 | ✍ | ⛔ | | 39560836 | Astragalus polysaccharide treatment relieves cerebral ischemia-reperfusion injury by promoting M2 polarization of microglia by enhancing O-GlcNAcylation |
| Coffee | 📋 | ✍ | ⛔ | | 40254465 | Investigating the causal association between coffee and migraine using Mendelian randomization analysis |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 39907901 | Grape Seed Extract Pretreatment Prevents Mitochondrial Dysfunction and NLRP3 Inflammasome-Induced Inflammatory Response in Glial Cells Exposed to Paroxetine and Quinolinic Acid |
| Kaempferol | 📋 | ✍ | ⛔ | | 40139421 | Efficacy of mangiferin, kaempferol, and diosgenin on models of depression: A systematic review and network meta-analysis of rodent studies |
| Allicin | 📋 | ✍ | ⛔ | | 40396992 | Alliin from garlic as a neuroprotective agent attenuates ferroptosis in vitro and in vivo via inhibiting ALOX15 |
| Carvacrol | 📋 | ✍ | ⛔ | | 40401344 | Cyclophosphamide Induces Glioblastoma Tumor Cell Death and Oxidative Stress Through the Increase of TRPM2 Channel Stimulation: The Role of Carvacrol |
| Catalpol | 📋 | | | | 40245961 | IGF-1 signaling pathway activation promotes axonal regeneration and repair: A mechanism study on catalpol-induced functional recovery after ischemic stroke |
| Cinnamon | 📋 | ✍ | ⛔ | | 40259962 | Cinnamon pretreatment modulates gene expression of tight junction proteins in a rat model of stroke |
| Frankincense | 📋 | ✍ | ⛔ | | 38250661 | Autophagy machinery plays an essential role in traumatic brain injury-induced apoptosis and its related behavioral abnormalities in mice: focus on Boswellia Sacra gum resin |
| Silibinin | 📋 | ✍ | | | 40280368 | Silibinin protects the ischemic brain in mice by exerting anti-apoptotic effects via the EGFR/ERK pathway |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 39770466 | Documentary Analysis of Hypericum perforatum (St. John's Wort) and Its Effect on Depressive Disorders |
| Urolithins | 📋 | | | | 40449618 | Neuroprotective effects of urolithin a in a mouse model of intracerebral hemorrhage |
| Folate | 📋 | ✍ | ⛔ | | 39533580 | Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study |
| Fucoidan | 📋 | ✍ | ⛔ | | 39736397 | Exposure to an enriched environment and fucoidan supplementation ameliorate learning and memory function in rats subjected to global cerebral ischemia |
| Taurine | 📋 | ✍ | ⛔ | | 40361025 | Unveiling taurine's protective role in ischemic stroke: insights from bidirectional Mendelian randomization and LC-MS/MS analysis |
| TUDCA | 📋 | ✍ | ⛔ | | 40490087 | Tauroursodeoxycholic acid reduces brain lesion volume and cortical edema in a rat model of Traumatic brain injury |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 40411246 | Systematic Review Suggests Nutraceuticals Containing Vitamin B2 Could Provide an Alternative Treatment for Paediatric Migraines |
| Antioxidants | 📋 | | ⛔ | | 40018917 | The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer's Disease |
| Coconut Oil | 📋 | | ⛔ | | 39446626 | Effects of Krill Oil and Coconut Oil on Inflammatory Processes in Rats With Chronic Unpredictable Mild Stress-Induced Depression and Obesity Model |
| Formononetin | 📋 | | | | 40464507 | The Role of Formononetin in Cerebral Ischemia-Reperfusion Injury: A New Mediator of c-Fos/IL-10/STAT3 Signaling Pathway |
| Mangiferin | 📋 | | ⛔ | | 40474971 | Mangiferin mitigates neurological deficits and ferroptosis via NRF2/ARE pathway activation in cerebral ischemia-reperfusion rats |
| Silymarin | 📋 | ✍ | ⛔ | | 39624169 | Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels |
| Tea | 📋 | | | | 40565663 | Tea and Its Active Ingredients in Preventing and Alleviating Depression: A Comprehensive Review |
| Anthocyanins | 📋 | ✍ | ⛔ | | 39226946 | A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions |
| Asiatic Acid | 📋 | | | | 40550866 | Asiatic acid potentiates the activity of common antidepressant drugs in mice |
| Flavonoids | 📋 | | ⛔ | | 40490174 | The relationship between flavonols intake and stroke in the elderly: a cross-sectional study from NHANES (2007-2010 and 2017-2018) |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 40272460 | Long-term fucoxanthin treatment prevents cognitive impairments and neuroinflammation via the inhibition of Nogo-A in APP/PS1 transgenic mice |
| Ginger | 📋 | ✍ | ⛔ | | 39829385 | Ginger leaf polyphenols mitigate β-amyloid toxicity via JNK/FOXO pathway activation in Caenorhabditis elegans |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 40272820 | Effects of Heat-Treated Green Tea Extract on Memory Function and Default Mode Network Connectivity in Individuals with Subjective Memory Impairment: A Randomized, Double-Blinded, Placebo-Controlled Trial |
| Scutellarin | 📋 | | | | 40232642 | Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia |
| Angelica | 📋 | ✍ | ⛔ | | 38154524 | Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice |
| Carotenoids | 📋 | ✍ | ⛔ | | 39834456 | Association between serum carotenoids levels and severe headache or migraine in adults: a cross-sectional study from NHANES |
| Dihydroquercetin | 📋 | | | | 39756058 | Dihydroquercetin Ameliorates Neuronal Ferroptosis in Rats After Subarachnoid Hemorrhage via the PI3K/AKT/Nrf2/HO-1 Pathway |
| Galangin | 📋 | | | | 40076473 | Galangin's Neuroprotective Role: Targeting Oxidative Stress, Inflammation, and Apoptosis in Ischemic Stroke in a Rat Model of Permanent Middle Cerebral Artery Occlusion |
| Gingerol | 📋 | ✍ | | | 40440961 | 6-Gingerol overcomes TMZ resistance in GBM by suppressing EMT and cell migration via the PI3K/Akt/β-catenin/c-Myc pathway |
| Honokiol | 📋 | | | | 40462120 | Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation |
| L-Carnitine | 📋 | ✍ | ⛔ | | 40243464 | L-Carnitine and Mildronate Demonstrate Divergent Protective Effects on Mitochondrial DNA Quality Control and Inflammation Following Traumatic Brain Injury |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 39810851 | Effect of ethanol extract of nigella sativa L seeds and propofol on BDNF protein level as neuroplasticity and neuroprotection of traumatic brain injury in rats |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 40251199 | Bacopa monnieri phytochemicals as promising BACE1 inhibitors for Alzheimer's disease therapy |
| Hydroxytyrosol | 📋 | | | | 38732018 | Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study |
| Lemon Balm | 📋 | ✍ | ⛔ | | 39458539 | Clinical Efficacy and Tolerability of Lemon Balm (Melissa officinalis L.) in Psychological Well-Being: A Review |
| Lutein | 📋 | ✍ | ⛔ | | 40134054 | Associations of dietary and plasma lutein + zeaxanthin with depression in US adults: findings from NHANES |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 39905292 | Molecular assessment of NMDAR subunits and neuronal apoptosis in the trigeminal ganglion in a model of male migraine-induced rats following Moringa oleifera alcoholic extract administration |
| Pine Bark | 📋 | ✍ | ⛔ | | 38299491 | Pycnogenol® improves cognitive function in post-stroke patients: a 6 month-study |
| Rosemary | 📋 | ✍ | ⛔ | | 40544322 | Differential neuroprotective mechanisms of rosemary and carnosic acid in cerebral ischemia-reperfusion injury |
| Schisandrins | 📋 | | | | 40382817 | Schisandrin B ameliorates Alzheimer's disease by suppressing neuronal ferroptosis and ensuing microglia M1 polarization |
| Skullcap | 📋 | ✍ | ⛔ | | 40077679 | The Effects of Combined Scutellaria and Saffron Supplementation on Mood Regulation in Participants with Mild-to-Moderate Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 39422945 | Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 39585054 | The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer's Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial |
| Prebiotics | 📋 | ✍ | ⛔ | | 40495848 | Gut-brain connection in schizophrenia: A narrative review |
| Benfotiamine | 📋 | ✍ | ⛔ | | 40176579 | Evaluation of neuroprotective role of benfotiamine in Alzheimer's disease model: A randomized control study |
| Choline | 📋 | ✍ | ⛔ | | 40447055 | Dietary Choline Intake and Risk of Alzheimer's Dementia in Older Adults |
| Emodin | 📋 | | ⛔ | | 40461604 | Emodin influences pyroptosis-related Caspase 1-GSDMD axis alleviated cerebral ischemia-reperfusion injury in rats |
| L-Carnosine | 📋 | ✍ | ⛔ | | 39933073 | Carnosine Mitigates Cognitive Impairment and Dopamine Release in an Okadaic Acid-Induced Zebrafish Model with Alzheimer's Disease-like Symptoms |
| Ligustilide | 📋 | | | | 38021448 | Anti-Glioma Effects of Ligustilide or n-Butylphthalide on Their Own and the Synergistic Effects with Temozolomide via PI3K/Akt Signaling Pathway |
| Mulberry | 📋 | | ⛔ | | 39172975 | Antidepressant-like and antioxidant effects of Morus nigra L. in rats subjected to the unpredictable chronic mild stress model |
| Vitamin B Complex | 📋 | | ⛔ | | 40093527 | Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| Arctigenin | 📋 | | | | 40206088 | Neuroprotective effects of arctigenin on cerebral ischemia-reperfusion injury in rats via the EPO/EPOR-JAK2-STAT5 signaling pathway |
| Betaine | 📋 | ✍ | ⛔ | | 39276097 | Prophylactic Effects of Betaine on Depression and Anxiety Behaviors in Mice with Dextran Sulfate Sodium-Induced Colitis |
| Bilobalide | 📋 | | | | 37615035 | Suppressive effects of bilobalide on depression-like behaviors induced by chronic unpredictable mild stress in mice |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 40346511 | Identifying suppressive factors of Alzheimer's disease through comprehensive analysis of real-world data: a single-center retrospective study |
| Holy Basil | 📋 | ✍ | ⛔ | | 37763282 | Ocimum sanctum Alters the Lipid Landscape of the Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in a Mouse Model |
| Icaritin | 📋 | | | | 40318814 | Icaritin Promotes Brain Functional Rehabilitation in Ischemic Stroke Rats by Regulating Astrocyte Activation and Polarization Via GPER |
| Tangeretin | 📋 | | | | 40320970 | Tangeretin Improves the Memory of Swiss Mice, Suggesting Potential Molecular Interventions Through Animal Behavior Assessments and In Silico Studies |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 40134054 | Associations of dietary and plasma lutein + zeaxanthin with depression in US adults: findings from NHANES |
| Aged Garlic | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| DHEA | 📋 | ✍ | ⛔ | | 40437391 | Androgens alleviate the depression-like phenotype in female mice by inhibiting AVPR1a in the hippocampal brain region |
| Grape | 📋 | | ⛔ | | 39821885 | Effectiveness of Grape-Based Interventions on Cognitive and Mental Health: Evidence From Human Trials |
| Hesperetin | 📋 | | | | 38517352 | Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids |
| L-Arginine | 📋 | ✍ | ⛔ | | 39326233 | L-arginine mitigates choroid plexus changes in Alzheimer's disease rat model via oxidative/inflammatory burden and behavioral modulation |
| Licorice Root | 📋 | ✍ | ⛔ | | 39757620 | Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer's Disease |
| Nicotinamide | 📋 | ✍ | ⛔ | | 40159484 | Cognitive impairment following maternal separation in rats mediated by the NAD+/SIRT3 axis via modulation of hippocampal synaptic plasticity |
| Oleuropein | 📋 | | | | 39704928 | Protective effect of oleuropein on the brain tissue in D-Galactose-induced aging in rat model |
| Sage | 📋 | ✍ | ⛔ | | 40151497 | Hydroethanolic Extract of Salvia officinalis L. Leaves Improves Memory and Alleviates Neuroinflammation in ICR Mice |
| Artemisinin | 📋 | | | | 39746391 | Neuronal protective effect of Artemisinin in ischemic stroke: Achieved by blocking lysine demethylase 1A-mediated demethylation of sphingosine kinase 2 |
| Asiaticoside | 📋 | | | | 39931216 | Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway |
| Calycosin | 📋 | | | | 40348321 | Calycosin regulates gut microbiota-bile acid-FXR axis to protect rats from cerebral ischemia-reperfusion injury |
| Cordycepin | 📋 | | | | 40103703 | Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in A?1-42-induced neuronal cell models |
| Crocetin | 📋 | | | | 39092730 | Crocetin Enhances Temozolomide Efficacy in Glioblastoma Therapy Through Multiple Pathway Suppression |
| Diosmin | 📋 | ✍ | ⛔ | | 40261347 | Behavioral deficits after traumatic brain injury: Neuroprotective effect of Diosmin |
| Ganoderic Acid | 📋 | | | | 40054827 | The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 39988819 | Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A Narrative Review |
| Spirulina | 📋 | ✍ | ⛔ | | 39565401 | Aqueous extract of Spirulina exerts neuroprotection in an experimental model of Alzheimer sporadic disease in mice induced by Streptozotocin |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 40395549 | The relationship between dietary vitamin B1 and stroke: a machine learning analysis of NHANES data |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 40082970 | The effects of concurrent alpha-linolenic acid, L-carnitine supplementation on clinical symptoms, mental health, and quality of life in women with migraine: a randomized, triple-blind, placebo-controlled trial |
| Aspirin | 📋 | | ⛔ | | 39920681 | The mechanisms of efficacy and safety of Ginkgo biloba extract in acute ischemic stroke: a real-world study |
| Bee Propolis | 📋 | ✍ | ⛔ | | 38583392 | Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice |
| Black Pepper | 📋 | ✍ | ⛔ | | 36435434 | Effects of dichloromethane extraction from Piper nigrum L. and P. longum L. on the expression of autophagy-related proteins in ischemic stroke |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 36159806 | Tryptophan metabolism: Mechanism-oriented therapy for neurological and psychiatric disorders |
| Magnolol | 📋 | | | | 40470630 | Magnolol improves postoperative cognitive dysfunction in aged mice by activating the nuclear factor erythroid 2-related factor 2/antioxidant response element pathway |
| Red Sage | 📋 | ✍ | ⛔ | | 38772181 | Mechanism of Salvia miltiorrhiza Bunge extract to alleviate Chronic Sleep Deprivation-Induced cognitive dysfunction in rats |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 35738179 | Resistance training and Urtica dioica increase neurotrophin levels and improve cognitive function by increasing age in the hippocampus of rats |
| Valerian Root | 📋 | ✍ | ⛔ | | 36829235 | Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway |
| Catechins | 📋 | | | | 40172817 | Neuroprotective Effects of Catechins by Differentially Affecting the Binding of Beta-amyloid and Its Aggregates to the Target Cells |
| Chokeberry | 📋 | ✍ | ⛔ | | 38656355 | Short-term Aronia melanocarpa extract supplementation improves cognitive performance: a randomized, double-blind, placebo-controlled cross-over study in healthy young adults |
| Cinnamaldehyde | 📋 | | | | 40381675 | Cinnamaldehyde enhances the intervention effect of puerarin on stroke from the perspectives of pharmacokinetics and pharmacodynamics |
| Eugenol | 📋 | | | | 40432346 | Eugenol Alleviates Cerebral Ischemia-Reperfusion Injury in Mice by Promoting the Phagocytosis of Microglia via Up-Regulating Tripartite Motif Protein 59 |
| Fish | 📋 | | ⛔ | | 40219009 | Extent of Unidentified Complaints and Depression Is Inversely Associated with Fish and Shellfish Intake in Young Japanese Women |
| Myricetin | 📋 | | ⛔ | | 40383238 | Myricetin alleviates learning and memory deficits in trimethyltin Alzheimer's phenotype via attenuating hippocampal endoplasmic reticulum stress and regulating inflammation and oxidative stress |
| Nuts | 📋 | | ⛔ | | 39940379 | Nut Consumption Is Associated with Cognitive Status in Southern Italian Adults |
| Peony | 📋 | | ⛔ | | 39771032 | Investigation into the Potential Mechanism of Radix Paeoniae Rubra Against Ischemic Stroke Based on Network Pharmacology |
| Persimmon | 📋 | | ⛔ | | 37115470 | Therapeutic effects of a standardized-flavonoid Diospyros kaki L.f. leaf extract on transient focal cerebral ischemia-induced brain injury in mice |
| Punicalagin | 📋 | ✍ | ⛔ | | 39313488 | Ellagitannin Component Punicalin Ameliorates Cognitive Dysfunction, Oxidative Stress, and Neuroinflammation via the Inhibition of cGAS-STING Signaling in the Brain of an Aging Mouse Model |
| Rapamycin | 📋 | ✍ | | | 38640155 | Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies |
| Spikenard | 📋 | ✍ | ⛔ | | 40027104 | Integration of phytochemical profiling and computational approaches to evaluate the neuroprotective potential of Nardostachys jatamansi in Alzheimer's disease |
| Thymol | 📋 | ✍ | ⛔ | | 39009094 | Thymol improves ischemic brain injury by inhibiting microglia-mediated neuroinflammation |
| Biochanin A | 📋 | | | | 40012390 | Biochanin-A: A Potential Candidate for the Treatment of Alzheimer's Disease |
| Carnosic Acid | 📋 | | | | 40544322 | Differential neuroprotective mechanisms of rosemary and carnosic acid in cerebral ischemia-reperfusion injury |
| Daidzein | 📋 | ✍ | ⛔ | | 40359691 | Daidzein effectively mitigates amyloid-β-induced damage in SH-SY5Y neuroblastoma cells and C6 glioma cells |
| Garlic | 📋 | ✍ | ⛔ | | 40512569 | Therapeutic and Biological Properties of White Garlic and Black Garlic Extracts (Allium sativum L.): A Comparative Analysis |
| Wogonin | 📋 | ✍ | ⛔ | | 38253131 | Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1 |
| Wormwood | 📋 | ✍ | ⛔ | | 38893336 | In Vitro and In Silico Anti-Glioblastoma Activity of Hydroalcoholic Extracts of Artemisia annua L. and Artemisia vulgaris L |
| Aloe-Emodin | 📋 | | | | 40125832 | Aloe-Emodin Improves Mitophagy in Alzheimer's Disease via Activating the AMPK/PGC-1α/SIRT3 Signaling Pathway |
| Diosgenin | 📋 | | | | 40430556 | Neuroprotective Effects of Qi Jing Wan and Its Active Ingredient Diosgenin Against Cognitive Impairment in Plateau Hypoxia |
| Escin | 📋 | ✍ | ⛔ | | 40095493 | Pharmacological Evaluation of Aescin for Neuroprotection in Intracerebroventricular Streptozotocin Model of Alzheimer's Disease in Experimental Rats |
| Fenugreek | 📋 | ✍ | ⛔ | | 40125337 | Anti-inflammatory and antioxidant effects of fenugreek in preventing mice model of Alzheimer's disease |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 40474979 | Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota |
| Haritaki | 📋 | ✍ | ⛔ | | 39494343 | The potential of Terminalia chebula in alleviating mild cognitive impairment: a review |
| Hyperoside | 📋 | | | | 39647288 | Hyperoside alleviates depressive-like behavior in social defeat mice by mediating microglial polarization and neuroinflammation via TRX1/NLRP1/Caspase-1 signal pathway |
| Nattokinase | 📋 | ✍ | ⛔ | | 39713256 | Natural serine proteases and their applications in combating amyloid formation |
| Pregnenolone | 📋 | ✍ | ⛔ | | 35721911 | Pregnenolone Attenuates the Ischemia-Induced Neurological Deficit in the Transient Middle Cerebral Artery Occlusion Model of Rats |
| Progesterone | 📋 | ✍ | ⛔ | | 40532869 | The effects of progesterone administration and pre-training on learning & memory, anxiety-like behaviors, and balance impairments following traumatic brain injury in male rats: The role of neuroinflammation |
| Rhodiola | 📋 | ✍ | ⛔ | | 35745023 | The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence |
| Senolytics | 📋 | | | | 39568081 | Cellular senescence in Alzheimer's disease: from physiology to pathology |
| Spermidine | 📋 | | | | 40503490 | Spermidine Exerts Neuroprotective Effects Following Intracerebral Hemorrhage in Mice Through Anti-Inflammation and Blood-Brain Barrier Protection |
| 5-HTP | 📋 | ✍ | ⛔ | | 37421347 | Effects of adjuvant berberine therapy on acute ischemic stroke: A meta-analysis |
| Balloon Flower | 📋 | ✍ | ⛔ | | 40333841 | Role of Saponins from Platycodon grandiflorum in Alzheimer's Disease: DFT, Molecular Docking, and Simulation Studies in Key Enzymes |
| Bee Venom | 📋 | ✍ | ⛔ | | 38252207 | Melitoxin Inhibits Proliferation, Metastasis, and Invasion of Glioma U251 Cells by Down-regulating F2RL1 |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 40158533 | Potential roles of inhalation aromatherapy on stress-induced depression by inhibiting inflammation in the peripheral olfactory system |
| Cordyceps | 📋 | ✍ | ⛔ | | 40508211 | Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease |
| Echinacoside | 📋 | | | | 38569512 | Beneficial effects of Echinacoside on cognitive impairment and diabetes in type 2 diabetic db/db mice |
| Gardenia | 📋 | | ⛔ | | 40184133 | Study on mechanism of iridoid glycosides derivatives from Fructus Gardeniae in treatment of hepatic encephalopathy by network pharmacology and molecular docking technology |
| Geraniol | 📋 | | | | 39587789 | Protective effects of geraniol in a male rat model of Alzheimer's disease: A behavioral, biochemical, and histological study |
| Ginger extract | 📋 | ✍ | ⛔ | | 40129204 | Investigation of the Protective and Therapeutic Effects of Ginger (Zingiber officinale) Extracts on Neuroinflammatory, Motor and Cognitive Impairments Caused by Mild Traumatic Brain Injury Model |
| Indian Gooseberry | 📋 | | ⛔ | | 39624549 | An Experimental Study to Evaluate the Antidepressant Effect of Zileuton and Aqueous Extract of Phyllanthus emblica in Unpredictable Chronic Mild Stress-Induced Depression in Albino Mice |
| Isoliquiritigenin | 📋 | | | | 40414556 | Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease |
| Morin | 📋 | | | | 39549093 | Morin Ameliorates Lipopolysaccharides-Induced Sepsis-Associated Encephalopathy and Cognitive Impairment in Albino Mice |
| Neferine | 📋 | | | | 38910141 | Neferine inhibits BMECs pyroptosis and maintains blood-brain barrier integrity in ischemic stroke by triggering a cascade reaction of PGC-1α |
| Paeonol | 📋 | | | | 39552449 | Paeonol Alleviates Subarachnoid Hemorrhage Injury in Rats Through Upregulation of SIRT1 and Inhibition of HMGB1/TLR4/MyD88/NF-ÎşB Pathway |
| PEA | 📋 | ✍ | ⛔ | | 40313591 | Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer's disease |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 33382357 | Pomegranate peel extract ameliorates the severity of experimental autoimmune encephalomyelitis via modulation of gut microbiota |
| PUFA | 📋 | | | | 39596544 | The Role of Alpha-Linolenic Acid and Other Polyunsaturated Fatty Acids in Mental Health: A Narrative Review |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 39990741 | The anti-depression effect and mechanism of harmonious rosemary essential oil and its application in microcapsules |
| SAMe | 📋 | ✍ | ⛔ | | 39743489 | S-adenosylmethionine supplementation to alleviate depression symptoms in patients with suboptimal response to standard antidepressive therapy: a perspective |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 40283984 | Soy Isoflavones Protects Against Stroke by Inhibiting Keap1/NQO1/Nrf2/HO-1 Signaling Pathway: Network Pharmacology Analysis Combined with the Experimental Validation |
| Tetrahydrocurcumin | 📋 | ✍ | | | 39936602 | Tetrahydrocurcumin exhibits neuroprotective effects by inhibiting neuron ferroptosis via activity of iPLA2β/p38 MAPK phosphorylation in rat TBI model |
| Vitamin A | 📋 | ✍ | ⛔ | | 40441192 | Serum vitamin levels and major depressive disorder: Age-dependent associations in the US adult population |
| Withaferin A | 📋 | | | | 40573212 | Withaferin A Rescues Brain Network Dysfunction and Cognitive Deficits in a Mouse Model of Alzheimer's Disease |
| Astragalin | 📋 | | | | 40089077 | Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 36982248 | β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 37864768 | Implication of Caffeic Acid for the Prevention and Treatment of Alzheimer's Disease: Understanding the Binding with Human Transferrin Using In Silico and In Vitro Approaches |
| Capsaicin | 📋 | ✍ | ⛔ | | 37373321 | A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 38229887 | Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease |
| Dihydroartemisinin | 📋 | | | | 39910679 | Therapeutic effect of dihydroartemisinin on Alzheimer's disease model mice with senile macular degeneration |
| Hawthorn | 📋 | ✍ | ⛔ | | 36447359 | Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model |
| Licochalcones | 📋 | | | | 39930360 | Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroinflammation mice model |
| Lotus | 📋 | | ⛔ | | 38983916 | Exploring the therapeutic potential of Nelumbo nucifera leaf extract against amyloid-beta-induced toxicity in the Caenorhabditis elegans model of Alzheimer's disease |
| Mushrooms | 📋 | | ⛔ | | 38634265 | Investigating the association between inflammation mediated by mushroom consumption and mild cognitive impairment in Chinese older adults |
| Patchouli | 📋 | ✍ | ⛔ | | 38996935 | The effect and mechanism of patchouli alcohol on cognitive dysfunction in AD mice induced by Aβ1-42 oligomers through AMPK/mTOR pathway |
| Polydatin | 📋 | ✍ | | | 40313624 | Polydatin attenuates Alzheimer's disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects |
| Pomegranate Seed extract | 📋 | | ⛔ | | 38306046 | The Effects of Pomegranate Seed Oil on Mild Cognitive Impairment |
| Roselle | 📋 | ✍ | ⛔ | | 40009760 | Acute effects of Hibiscus sabdariffa on blood pressure and cognitive function |
| Sesamol | 📋 | | | | 37848698 | Sesamol defends neuronal damage following cerebral ischemia/reperfusion: a crosstalk of autophagy and Notch1/NLRP3 inflammasome signaling |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 37876150 | Dietary Supplement with Tribulus terrestris L. Extract Exhibits Protective Effects on Ischemic Stroke Rats |
| Turmeric | 📋 | ✍ | ⛔ | | 39968002 | Investigating the Impact of Turmeric on Neuroinflammation and Degenerative Changes in Repetitive Traumatic Brain Injuries: Insights from Murine Model |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 38864135 | [Ursolic acid improved demyelination and interstitial fluid drainage disorders in schizophrenia mice] |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 37723526 | Dietary niacin intake in relation to depression among adults: a population-based study |
| Acacetin | 📋 | | | | 38114218 | [Acacetin protects rats from cerebral ischemia-reperfusion injury by regulating TLR4/NLRP3 signaling pathway] |
| Aloe Vera | 📋 | ✍ | ⛔ | | 40203444 | Effect of Aloe vera on brain indoleamine 2, 3 dioxygenase activity and tissue antioxidant status in rats subjected to swim stress |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 39850118 | Dietary supplements for prevention of Alzheimer's disease: In vivo and in silico molecular docking studies |
| CAPE | 📋 | | | | 39858474 | Caffeic Acid Phenethyl Ester Protects Neurons Against Oxidative Stress and Neurodegeneration During Traumatic Brain Injury |
| Cryptotanshinone | 📋 | | | | 40345007 | Cryptotanshinone promotes ferroptosis in glioblastoma via KEAP1/NRF2/HMOX1 signaling pathway |
| Galangal | 📋 | ✍ | ⛔ | | 36306920 | Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression |
| Ginkgetin | 📋 | | | | 35593977 | Ginkgetin Promotes M2 Polarization of Microglia and Exert Neuroprotection in Ischemic Stroke via Modulation of PPARγ Pathway |
| Kudzu Root | 📋 | ✍ | ⛔ | | 36330645 | Research on the material basis and mechanism of Kudzu root in preventing and treating cerebral ischemia based on network pharmacology |
| Mangosteen | 📋 | ✍ | ⛔ | | 35415207 | Effects of water-soluble mangosteen extract on cognitive function and neuropsychiatric symptoms in patients with mild to moderate Alzheimer's disease (WECAN-AD): A randomized controlled trial |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 40158533 | Potential roles of inhalation aromatherapy on stress-induced depression by inhibiting inflammation in the peripheral olfactory system |
| Safflower | 📋 | ✍ | ⛔ | | 39776584 | Carthamus tinctorius L. protects cerebral ischemia/reperfusion injury via arachidonic acid/p53-mediated apoptosis axis |
| Stigmasterol | 📋 | | | | 39364731 | Stigmasterol exerts antiglioma effects by regulating lipid metabolism |
| Vitexin | 📋 | | | | 40441663 | Vitexin alleviates cerebral ischemia/reperfusion injury by regulating mitophagy via the SIRT1/PINK1/Parkin pathway |
| Withanolides | 📋 | | | | 39721456 | The total withanolides from the leaves of Datura stramonium L. Improves Alzheimer's disease pathology by restraining neuroinflammation through NLRP3/IL-1β/IL1R1/TOM 1 pathway |
| Anise | 📋 | ✍ | ⛔ | | 37727035 | Protective effects of anise in prevention of cerebral ischemia reperfusion injury in rats |
| Apple Polyphenols | 📋 | | ⛔ | | 40386213 | Young apple polyphenol extract prevents diabetic cognitive dysfunction by promoting TET2-mediated active DNA demethylation in the brain of diabetic mice |
| Basil | 📋 | ✍ | ⛔ | | 36185698 | A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress |
| BCAA | 📋 | ✍ | ⛔ | | 36060454 | Branched-Chain Amino Acids Are Neuroprotective Against Traumatic Brain Injury and Enhance Rate of Recovery: Prophylactic Role for Contact Sports and Emergent Use |
| Chamomile | 📋 | ✍ | ⛔ | | 39957158 | Antidepressive and anxiolytic effects of a combination of Saffron and Chamomile in rats and their relationship with serotonin using methods |
| Coconut | 📋 | | ⛔ | | 39452493 | Administration of Young Coconut (Cocos nucifera L.) Juice Ameliorates Memory Impairment in a Menopausal Rat Model |
| Coptis Chinensis | 📋 | | ⛔ | | 40160459 | The potential role and mechanism of Rhizoma Coptidis in prevention of diabetic encephalopathy: targeting sodium ion and channels |
| Creatine | 📋 | ✍ | ⛔ | | 40395689 | Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition |
| Cyanidin | 📋 | ✍ | | | 40454491 | Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018 |
| Dioscin | 📋 | | | | 40391080 | Integrating experimental and network pharmacology to explore the pharmacological mechanisms of Dioscin against glioblastoma |
| Essential Oils | 📋 | | ⛔ | | 39921369 | Treatments of psychosomatic symptoms in Alzheimer's disease: a scoping review of the potential therapeutic effects of essential oils |
| Giloy | 📋 | ✍ | ⛔ | | 40057579 | Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer's disease |
| Guggulsterone | 📋 | | | | 37230158 | Novel synergistic mechanism of 11-keto-β-boswellic acid and Z-Guggulsterone on ischemic stroke revealed by single-cell transcriptomics |
| Hypericin | 📋 | | | | 40384041 | Hypericin Regulates Inflammation Levels and Improves Depressive Symptoms in Rats With Post-Stroke Depression Through the MEK/ERK/CREB Pathway |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 39844852 | Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice |
| Krill Oil | 📋 | ✍ | ⛔ | | 40118278 | The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial |
| Lavender | 📋 | ✍ | ⛔ | | 39600726 | Antidepressant-Like Effects of Lavandula angustifolia Mill (Lamiaceae) Aqueous and Total Crude Extracts in Wistar Albino Rats |
| Linalool | 📋 | | ⛔ | | 38723901 | Linalool acts as a chemical chaperone by inhibiting amyloid-β aggregation |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 39269844 | Correlation of the Serum Fatty Acids with Cognitive Function: An NHANES 2011-2014 and Multivariate Mendelian Randomization Analysis |
| Liquiritin | 📋 | | | | 38074876 | Antidepressant effect of licorice total flavonoids and liquiritin: A review |
| Magnolia | 📋 | ✍ | ⛔ | | 38955265 | Neolignans in Magnolia officinalis as natural anti-Alzheimer's disease agents: A systematic review |
| Oleanolic Acid | 📋 | | | | 40358968 | Oleanolic Acid Alleviates Neuronal Ferroptosis in Subarachnoid Hemorrhage by Inhibiting KEAP1-Nrf2 and NF-?B Pathways |
| Olive Polyphenols | 📋 | | | | 39482909 | Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load |
| Parthenolide | 📋 | | | | 39595109 | Neuronal Differentiation of Human Glioma Cells Induced by Parthenolide Under In Vitro Conditions |
| PQQ | 📋 | ✍ | ⛔ | | 38454653 | Deep Learning-Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 39984555 | Nebulized seabuckthorn seed oil inhalation attenuates Alzheimer's disease progression in APP/PS1 mice |
| Strawberry | 📋 | ✍ | ⛔ | | 35766389 | Impact of different processing methods on the phenolics and neuroprotective activity of Fragaria ananassa Duch. extracts in a D-galactose and aluminum chloride-induced rat model of aging |
| Syringic Acid | 📋 | | | | 40577513 | Syringic Acid Reduces Subarachnoid Hemorrhage-Induced Oxidative Damage in Rats |
| Tannic Acid | 📋 | ✍ | ⛔ | | 37712018 | A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease |
| Trehalose | 📋 | | ⛔ | | 37549864 | Effect of trehalose on miR-132 and SIRT1 in the hippocampus of aged rats |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 39881683 | The role of vitamin K2 in cognitive impairment: linking vascular health to brain health |
| Acai Berry | 📋 | ✍ | ⛔ | | 36904206 | Oral Treatment with the Extract of Euterpe oleracea Mart. Improves Motor Dysfunction and Reduces Brain Injury in Rats Subjected to Ischemic Stroke |
| Almond | 📋 | | ⛔ | | 34832965 | The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells |
| Anthocyanidins | 📋 | | | | 40454491 | Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018 |
| Berries | 📋 | | | | 35217779 | Effect of berry-based supplements and foods on cognitive function: a systematic review |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 38142848 | Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice |
| Bilberry | 📋 | ✍ | ⛔ | | 36414183 | Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury |
| Burdock | 📋 | | ⛔ | | 38669967 | Ethanolic extract of Arctium lappa leaves alleviates cerebral ischemia reperfusion-induced inflammatory injury via HDAC9-mediated NF-κB pathway |
| Calcium | 📋 | ✍ | ⛔ | | 35816459 | Calcium and magnesium in drinking water and risk of myocardial infarction and stroke - a population-based cohort study |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 37627529 | Direct Evidence for Using Coriandrum sativum var. microcarpum Essential Oil to Ameliorate Scopolamine-Induced Memory Impairment and Brain Oxidative Stress in the Zebrafish Model |
| Dandelion | 📋 | ✍ | ⛔ | | 35053874 | Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo |
| Diosmetin | 📋 | | | | 38460078 | Diosmetin Ameliorates HFD-induced Cognitive Impairments via Inhibiting Metabolic Disorders, Mitochondrial Dysfunction and Neuroinflammation in Male SD Rats |
| Eleuthero | 📋 | ✍ | ⛔ | | 40332373 | Acanthopanax Senticosus Saponins Prevent Cognitive Decline in Rats with Alzheimer's Disease |
| Fermented Foods | 📋 | | ⛔ | | 38280441 | Probiotic, prebiotic, synbiotic and fermented food supplementation in psychiatric disorders: A systematic review of clinical trials |
| Fiber | 📋 | ✍ | ⛔ | | 40589779 | Dietary fiber intake and hippocampal gray matter volume: an exploratory cross-sectional study in healthy adults |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 39374840 | Impacts of linseed oil diet on anxiety and memory extinction after early life stress: A sex-specific analysis of mitochondrial dysfunction, astrocytic markers, and inflammation in the amygdala |
| GABA | 📋 | ✍ | ⛔ | | 39377050 | GABA, Aging and Exercise: Functional and Intervention Considerations |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 39018691 | Epimedium flavonoids improve cerebral white matter lesions by inhibiting neuroinflammation and activating neurotrophic factor signal pathways in spontaneously hypertensive rats |
| Nootkatone | 📋 | | | | 39819316 | Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway |
| Oats | 📋 | | ⛔ | | 36657906 | Effect of Avena sativa (Oats) on cognitive function: A systematic review of randomized controlled trials |
| Phytoestrogens | 📋 | | ⛔ | | 39422947 | Alzheimer's Disease and (Phyto) Estrogen Treatment: Modification of Effects by Age, Type of Treatment, and Duration of Use |
| Postbiotics | 📋 | | | | 40495829 | Potential clinical benefits of probiotics, prebiotics, synbiotics, and postbiotics for depression via the microbiota-gut-brain axis |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 36917811 | Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways |
| Rehmannia | 📋 | ✍ | ⛔ | | 39539631 | Rehmannia glutinosa DC.-Lilium lancifolium Thunb. in the treatment of depression: a comprehensive review and perspectives |
| Shogaol | 📋 | | | | 40107601 | 6-shogaol alleviates excessive neuronal autophagy and calcium overload following cerebral ischemia-reperfusion injury by inhibiting the expression of DAPK1 |
| Tea Polyphenols | 📋 | | | | 40209346 | Effects of tea polyphenols and tea polysaccharides on improving nonylphenol-induced depression-like behavior, monoamine neurotransmitter disorder, and neuronal pyroptosis |
| Telmisartan | 📋 | | ⛔ | | 39679694 | Computational insights in repurposing a cardiovascular drug for Alzheimer's disease: the role of aromatic amino acids in stabilizing the drug through Ď-Ď stacking interaction |
| Trans-Resveratrol | 📋 | | | | 40362855 | Neuroprotective Effects of a Combination of Dietary Trans-Resveratrol and Hesperidin Against Methylglyoxal-Induced Neurotoxicity in a Depressive Amnesia Mouse Model |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37477796 | Vitamin K2 protects against aluminium chloride-mediated neurodegeneration |
| Vitamins | 📋 | | | | 38931257 | The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults |
| Andrographis | 📋 | ✍ | ⛔ | | 38057817 | Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 39531579 | Inhibitory Potency of Chlorogenic Acid from Apple Cider Vinegar Against Alzheimer's Disease: Molecular Docking and Dynamics Validation |
| Atractylodes | 📋 | ✍ | ⛔ | | 38178130 | Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke |
| Beets | 📋 | ✍ | ⛔ | | 38887650 | Exploring beetroot (Beta vulgaris L.) for diabetes mellitus and Alzheimer's disease dual therapy: in vitro and computational studies |
| Blackcurrant | 📋 | ✍ | ⛔ | | 39262284 | Blackcurrant (Ribes nigrum L.) improves cholinergic signaling and protects against chronic Scopolamine-induced memory impairment in mice |
| Boric Acid | 📋 | ✍ | ⛔ | | 37906374 | Boric acid Increases Susceptibility to Chemotherapy by Targeting the Ferritinophagy Signaling Pathway in TMZ Resistant Glioblastoma Cells |
| Bromelain | 📋 | ✍ | ⛔ | | 40491365 | Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 39560307 | Exploring the potential of Fargesin from Chrysanthemum indicum for chronic migraine: in-silico and pharmacokinetic study |
| Cornus | 📋 | | | | 40398794 | Cornel iridoid glycosides exerted neuroprotective effects against cerebral ischemia/reperfusion injury in rats via inhibiting TLR4/MyD88/NF-κB pathway |
| Cranberry | 📋 | ✍ | ⛔ | | 40442918 | Evaluation of Cranberry as a Novel Therapeutic Strategy for Intracerebroventricular (ICV) Quinolinic Acid-induced Cognitive Impairment in Rats |
| D-Limonene | 📋 | ✍ | ⛔ | | 39296804 | Synergism of d-limonene and temozolomide on migratory and apoptotic behaviors of human glioblastoma cell lines |
| Date | 📋 | | ⛔ | | 36654869 | Effects of Phoenix dactylifera against Streptozotocin-Aluminium Chloride Induced Alzheimer's Rats and Their In Silico Study |
| Egg | 📋 | | ⛔ | | 39686683 | Association between plant-based dietary patterns and cognitive function in middle-aged and older residents of China |
| Eucommia | 📋 | ✍ | ⛔ | | 40004043 | Eucommia ulmoides Oliv. Bark Extracts Alleviate MCAO/Reperfusion-Induced Neurological Dysfunction by Suppressing Microglial Inflammation in the Gray Matter |
| Fruits | 📋 | | | | 39536657 | The cross-sectional and longitudinal associations between fruit intake and cognitive performance: the Chinese Healthy Dance Study |
| Genipin | 📋 | | | | 39523775 | Repurposed genipin targeting UCP2 exhibits antitumor activity through inducing ferroptosis in glioblastoma |
| Glucosamine | 📋 | ✍ | ⛔ | | 39764251 | Causality of genetically determined glucosamine supplementation on cognition and sarcopenia: a Mendelian randomization study |
| Inulin | 📋 | ✍ | ⛔ | | 39568732 | Supplementation with inulin reverses cognitive flexibility alterations and modulates the gut microbiota in high-fat-fed mice |
| Isorhamnetin | 📋 | | | | 39933950 | Isorhamnetin Alleviates Inflammation-Induced Crosstalk between Kynurenine Pathway and Gut Microbiota in Depressed Mice |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38489176 | Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease |
| L-Leucine | 📋 | ✍ | ⛔ | | 37891741 | Leucine Reduced Blood-Brain Barrier Disruption and Infarct Size in Early Cerebral Ischemia-Reperfusion |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38924882 | NMN synbiotics intervention modulates gut microbiota and metabolism in APP/PS1 Alzheimer's disease mouse models |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 35706530 | Modified Citrus Pectin Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation via TLR4/NF-κB Signaling Pathway in Microglia |
| NAD | 📋 | | | | 40033213 | A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models |
| Neohesperidin | 📋 | | | | 39751909 | Neohesperidin Improves Depressive-Like Behavior Induced by Chronic Unpredictable Mild Stress in Mice |
| Nutmeg | 📋 | ✍ | ⛔ | | 35662922 | Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease |
| Peanut | 📋 | | ⛔ | | 35418581 | Peanut (Arachis hypogaea) sprout prevents high-fat diet-induced cognitive impairment by improving mitochondrial function |
| Pelargonidin | 📋 | | | | 36226369 | Pelargonidin inhibits vascularization and metastasis of brain gliomas by blocking the PI3K/AKT/mTOR pathway |
| Phloretin | 📋 | | | | 39496685 | Phloretin attenuates inflammation induced by subarachnoid hemorrhage through regulation of the TLR2/MyD88/NF-kB pathway |
| Procyanidins | 📋 | | ⛔ | | 39293861 | Procyanidin B1 Promotes PSMC3-NRF2 Ubiquitination to Induce Ferroptosis in Glioblastoma |
| Retinoic Acid | 📋 | | | | 37149281 | Retinoic acid has neuroprotective effects by modulating thioredoxin in ischemic brain damage and glutamate-exposed neurons |
| Safranal | 📋 | | | | 38234630 | Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1 |
| Sesamin | 📋 | ✍ | | | 36847969 | Effects of sesamin on Aβ1-42-induced oxidative stress and LTP impairment in a rat model of Alzheimer's disease |
| Spearmint | 📋 | | ⛔ | | 40467024 | Spearmint extract Neumentix downregulates amyloid-β accumulation by promoting phagocytosis in APP23 mice |
| Vitamin K | 📋 | ✍ | ⛔ | | 40428819 | Exploring the Link Between Vitamin K and Depression: A Systematic Review |
| Alpha GPC | 📋 | ✍ | ⛔ | | 39765138 | Treatment with soybean lecithin-derived α-GPC (SHCog™) improves scopolamine-induced cognitive declines in mice via regulating cholinergic neurotransmission and enhancing neural plasticity in the hippocampus |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 39276427 | Association of open skill exercise and long-chain polyunsaturated fatty acid intake with brain volume changes among older community-dwelling Japanese individuals |
| Asafoetida | 📋 | ✍ | ⛔ | | 38520834 | Kellerin alleviates cerebral ischemic injury by inhibiting ferroptosis via targeting Akt-mediated transcriptional activation of Nrf2 |
| Asparagus | 📋 | | ⛔ | | 40454371 | Exploring the neuroprotective role of Asparagus racemosus (Shatavari) in Alzheimer's disease: mechanisms, evidence, and future directions |
| Bay Leaf | 📋 | | ⛔ | | 37689325 | Neuroprotective and anti-amnesic effects of Laurus Nobilis essential oil against scopolamine-induced memory deficits in mice brain |
| Black Tea | 📋 | ✍ | ⛔ | | 34795745 | Effects of black tea consumption and caffeine intake on depression risk in black tea consumers |
| Boron | 📋 | ✍ | ⛔ | | 39515586 | Boron: An intriguing factor in retarding Alzheimer's progression |
| Butyrate | 📋 | | ⛔ | | 38532150 | Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach |
| Cardamom | 📋 | ✍ | ⛔ | | 39673650 | Targeting Neuroinflammation and Apoptosis: Cardamonin's Cognitive Benefits in Alzheimer's 5XFAD Mice |
| Carnosol | 📋 | | | | 36775042 | Carnosol inhibits cerebral ischemia-reperfusion injury by promoting AMPK activation |
| Cat's Claw | 📋 | ✍ | ⛔ | | 33589649 | In vitro comparison of major memory-support dietary supplements for their effectiveness in reduction/inhibition of beta-amyloid protein fibrils and tau protein tangles: key primary targets for memory loss |
| Cherry | 📋 | | ⛔ | | 40077655 | Assessing the Role of Dark Sweet Cherry (Prunus avium L.) Consumption on Cognitive Function, Neuropeptides, and Circadian Rhythm in Obesity: Results from a Randomized Controlled Trial |
| Chlorella | 📋 | ✍ | ⛔ | | 37144207 | Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease |
| Clove Essential Oil | 📋 | | ⛔ | | 40012817 | The Effects of Aromatherapy With Clove and Lavender on Headache Caused by Spinal Anesthesia in Patients Undergoing Urological Surgery: A Randomized Clinical Trial Study |
| Coriander | 📋 | | ⛔ | | 37513187 | Coriandrum sativum and Its Utility in Psychiatric Disorders |
| Coumaric acid | 📋 | | | | 37414223 | p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model |
| Equol | 📋 | ✍ | ⛔ | | 39408343 | Equol Nonproducing Status as an Independent Risk Factor for Acute Cardioembolic Stroke and Poor Functional Outcome |
| Feverfew | 📋 | ✍ | ⛔ | | 38204302 | Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study |
| Fig | 📋 | | ⛔ | | 40288909 | Dietary Ficus carica Inhibits Cognitive Impairment in Hypoxia-induced Non-alcoholic Fatty Liver Disease |
| Honey | 📋 | ✍ | ⛔ | | 37570596 | Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids |
| Jujube | 📋 | | ⛔ | | 38562322 | Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models |
| L-Lysine | 📋 | ✍ | ⛔ | | 27031721 | A Nutrient Mixture Inhibits Glioblastoma Xenograft U-87 MG Growth in Male Nude Mice |
| Lingonberry | 📋 | | ⛔ | | 40076984 | Revealing Lingonberry's Neuroprotective Potential in Alzheimer's Disease Through Network Pharmacology and Molecular Docking |
| Liquiritigenin | 📋 | | | | 33965487 | Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease |
| Long Pepper | 📋 | | ⛔ | | 37821784 | The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction |
| Maitake Mushrooms | 📋 | | ⛔ | | 32450016 | A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice |
| Malvidin | 📋 | | | | 40454491 | Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018 |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 39585071 | Mucuna pruriens, a Possible Treatment for Depressive Disorders |
| Nuciferine | 📋 | | | | 40347924 | Nuciferine ameliorates blood-brain barrier disruption post-ischemic stroke via inhibiting the JAK2/STAT3 pathway |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 37971997 | Association between the intake of dietary n3 and n6 fatty acids and stroke in US adults: A cross-sectional study of NHANES 2007-2018 |
| Orange | 📋 | | ⛔ | | 36678510 | Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 33463729 | Effects of diffused essential oils for reducing stress and improving mood for clinical nurses: An interventional time series study |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35201555 | A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 33163896 | Effects of a Nutritional Formulation Containing Caprylic and Capric Acid, Phosphatidylserine, and Docosahexaenoic Acid in Streptozotocin-Lesioned Rats |
| Piperlongumine | 📋 | | | | 39692457 | Piperlongumine inhibits glioblastoma proliferation by inducing ferroptosis |
| Quercitrin | 📋 | | | | 36292931 | The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway |
| Royal Jelly | 📋 | ✍ | ⛔ | | 38657030 | Comparative neuroprotective effects of royal jelly and its unique compound 10-hydroxy-2-decenoic acid on ischemia-induced inflammatory, apoptotic, epigenetic and genotoxic changes in a rat model of ischemic stroke |
| Sage Essential Oil | 📋 | | ⛔ | | 32549250 | Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice |
| Seaweeds | 📋 | | ⛔ | | 40137277 | The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments |
| Shilajit | 📋 | ✍ | ⛔ | | 37846531 | Investigation of Neuroprotective Effect of Shilajit Extract in Experimental Head Trauma Model Created in Rats |
| Soy | 📋 | ✍ | ⛔ | | 36117647 | Soy product consumption and the risk of major depressive disorder in older adults: Evidence from a cohort study |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 32416962 | Cerebral Deficiency of Vitamin B5 (D-Pantothenic Acid; Pantothenate) as a Potentially-Reversible Cause of Neurodegeneration and Dementia in Sporadic Alzheimer's Disease |
| Aloin | 📋 | | | | 33099296 | Inhibition of NOX2 contributes to the therapeutic effect of aloin on traumatic brain injury |
| Anethole | 📋 | | | | 40366448 | Anethole Ameliorates Scopolamine-Induced Memory Deficits and Neuronal Damage Through Antioxidant, Anti-Inflammatory, and Anticholinesterase Activities in Rats |
| Apple | 📋 | | ⛔ | | 35167638 | Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression- and anxiety-like behavior in mice by abating oxidative stress, inflammation and apoptosis via the miR-22-3p/SIRT1 axis |
| Barley | 📋 | ✍ | ⛔ | | 40339838 | Barley polysaccharides modulate metabolic and mild cognitive impairment in naturally aging mice through the liver-gut-brain axis |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 32155616 | The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 37758316 | Biochemical Mechanisms of Beneficial Effects of Beta-Alanine Supplements on Cognition |
| Betulinic Acid | 📋 | | | | 39965807 | Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways |
| Bitter Orange | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Blackberry | 📋 | | ⛔ | | 39258621 | Impact of daily administration of blackberry extract on gerbil model of transient cerebral ischemia |
| Camellia | 📋 | | ⛔ | | 40314670 | Insights into in silico analysis to explore the multitarget antidepressant role of Camellia sinensis |
| Cardamonin | 📋 | | | | 39673650 | Targeting Neuroinflammation and Apoptosis: Cardamonin's Cognitive Benefits in Alzheimer's 5XFAD Mice |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 40429872 | INO10, a Chaga Mushroom Extract, Alleviates Alzheimer's Disease-Related Pathology and Cognitive Deficits in 3xTg-AD Mice |
| Cheese | 📋 | | ⛔ | | 38694223 | Association between cheese and fish consumption and the occurrence of depression based on European population: mediating role of metabolites |
| Cinnamic Acid | 📋 | | | | 35325888 | Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice |
| Citral | 📋 | | | | 38999975 | Expanding Knowledge about the Influence of Citral on Cognitive Functions-In Vitro, In Vivo and Ex Vivo Studies |
| Clove | 📋 | | ⛔ | | 37851769 | Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 39372701 | A dietary intervention with conjugated linoleic acid enhances microstructural white matter reorganization in experimental stroke |
| Copper | 📋 | ✍ | ⛔ | | 36195639 | Brain copper may protect from cognitive decline and Alzheimer's disease pathology: a community-based study |
| DIM | 📋 | ✍ | ⛔ | | 39909809 | 3,3'-Diindolylmethane improves pathology and neurological outcome following traumatic brain injury |
| Echinacea | 📋 | ✍ | ⛔ | | 29215298 | Echinacea Purpurea Protects Against Restraint Stress-Induced Immunosuppression in BALB/c Mice |
| Elderberry | 📋 | ✍ | ⛔ | | 40002317 | Preliminary Effects of American Elderberry Juice on Cognitive Functioning in Mild Cognitive Impairment Patients: A Secondary Analysis of Cognitive Composite Scores in a Randomized Clinical Trial |
| Eucalyptol | 📋 | | | | 35028340 | Baiap3 regulates depressive behaviors in mice via attenuating dense core vesicle trafficking in subsets of prefrontal cortex neurons |
| Eucalyptus | 📋 | ✍ | ⛔ | | 39486370 | Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer's disease |
| Ginkgolic Acid | 📋 | | | | 39870805 | Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer's disease |
| Isoquercitrin | 📋 | | | | 37391332 | Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress |
| Jasmine | 📋 | | ⛔ | | 40253129 | Jasmine tea extract prevents CUMS-induced depression-like behaviors through the modulation of microbiota-gut-brain axis |
| L-Citrulline | 📋 | ✍ | ⛔ | | 33940559 | Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease |
| Lauric Acid | 📋 | ✍ | | | 40418323 | Effects of lauric acid on cognitive impairment in a scopolamine-induced Alzheimer's disease-like rat model |
| Lecithin | 📋 | ✍ | ⛔ | | 40344642 | Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 33723134 | In vitro cytotoxicity of cardamom oil, lemon oil, and jasmine oil on human skin, gastric, and brain cancer cell line |
| Lupeol | 📋 | | | | 38842663 | Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia |
| Lychee | 📋 | | ⛔ | | 31917277 | Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway |
| Maca Root | 📋 | ✍ | ⛔ | | 39852155 | A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca Lepidium meyenii |
| Mango | 📋 | | ⛔ | | 39211673 | Assessment of Efficacy and Safety of Mangifera indica Extract (Stadice®) for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Study |
| Marjoram Essential Oil | 📋 | | ⛔ | | 39858532 | Neuroprotective Potential of Origanum majorana L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model |
| Matcha Tea | 📋 | | | | 36771286 | Matcha Tea Powder's Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress |
| Morusin | 📋 | | | | 39740503 | Morusin regulates the migration of M2 macrophages and GBM cells through the CCL4-CCR5 axis |
| Myrtle | 📋 | ✍ | ⛔ | | 33475094 | Myrtus communis improves cognitive impairment in renovascular hypertensive rats |
| Oleic Acid | 📋 | | ⛔ | | 34040528 | Combined Oral and Topical Application of Pumpkin ( Cucurbita pepo L.) Alleviates Contact Dermatitis Associated With Depression Through Downregulation Pro-Inflammatory Cytokines |
| Oolong Tea | 📋 | | ⛔ | | 35629970 | Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice |
| Papaya | 📋 | ✍ | ⛔ | | 40457195 | Antidepressant potential of Carica Papaya fruit extract and diet: behavioral and physiological effects in mice models |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 24236576 | NMDA receptors and the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway are implicated in the antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice |
| Perilla | 📋 | ✍ | | | 37355083 | Antidepressant effect of Perilla frutescens essential oil through monoamine neurotransmitters and BDNF/TrkB signal pathway |
| Pistachio | 📋 | ✍ | ⛔ | | 38943918 | Pistachio (Pistacia vera L.) consumption improves cognitive performance and mood in overweight young adults: A pilot study |
| Pomelo | 📋 | | ⛔ | | 35571242 | Pomelo Peel Essential Oil Ameliorates Cerebral Ischemia-Reperfusion Injury through Regulating Redox Homeostasis in Rats and SH-SY5Y Cells |
| Potassium | 📋 | ✍ | ⛔ | | 28877896 | Intake of potassium- and magnesium-enriched salt improves functional outcome after stroke: a randomized, multicenter, double-blind controlled trial |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 39991095 | Pyridoxal 5'-phosphate and risk of stroke: triangulation of evidence from a nationally representative cohort and bidirectional Mendelian randomization analysis |
| Raspberry | 📋 | ✍ | ⛔ | | 38757671 | Raspberry Ketone Prevents LPS-Induced Depression-Like Behaviors in Mice by Inhibiting TLR-4/NF-κB Signaling Pathway via the Gut-Brain Axis |
| Rhubarb | 📋 | | ⛔ | | 38668344 | The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways |
| Rosehip | 📋 | ✍ | ⛔ | | 40362451 | Ethanolic Extract of Rosa rugosa Roots and Its Bioactive Compound, Oleamide, Prevented Amyloid ?-Induced Oxidative Stress and Improved Behavioral Tests in Mice |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 26788112 | Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell |
| Seafood | 📋 | | | | 39956386 | Seafood and neurocognitive development in children: A systematic review |
| Star Fuit | 📋 | | ⛔ | | 30196278 | Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease |
| Sunflower Oil | 📋 | ✍ | ⛔ | | 39973828 | Exploring the mechanism of sunflower seed oil against Alzheimer's disease through experimental and network pharmacology studies |
| Theaflavins | 📋 | ✍ | | | 31638230 | Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA-128-3p-mediated Nrf2 inhibition and reducing oxidative stress |
| Thyme Essential Oil | 📋 | | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 39035497 | The protective effect of biotin supplementation and swimming training on cognitive impairment and mental symptoms in a rat model of Alzheimer's disease: A behavioral, biochemical, and histological study |
| Vitamin K2 mk-4 | 📋 | ✍ | | | 38727984 | Menaquinone-4 Alleviates Neurological Deficits Associated with Intracerebral Hemorrhage by Preserving Corticospinal Tract in Mice |
| Whey Protein | 📋 | ✍ | ⛔ | | 39571910 | Effect of a 12-month intervention with whey protein powder on cognitive function in older adults with mild cognitive impairment: a randomized controlled trial |
| Yam | 📋 | | | | 35777608 | Study on the pharmacodynamic effect of Rhizoma Dioscoreae polysaccharides on cerebral ischemia-reperfusion injury in rats and the possible mechanism |
| Arctiin | 📋 | | | | 39136502 | Therapeutic Effects of Arctiin on Alzheimer's Disease-like Model in Rats by Reducing Oxidative Stress, Inflammasomes and Fibrosis |
| Bergamot | 📋 | ✍ | ⛔ | | 28591067 | Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia: Data From an 8-Week, Open-Label Pilot Study |
| Beta-Cryptoxanthin | 📋 | | | | 32435993 | Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor development in offspring at 2 years of age |
| Bitter Melon | 📋 | ✍ | ⛔ | | 36902074 | The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease |
| Black Ginger | 📋 | ✍ | ⛔ | | 40063637 | Kaempferia parviflora extract and its methoxyflavones as potential anti-Alzheimer assessing in vitro, integrated computational approach, and in vivo impact on behaviour in scopolamine-induced amnesic mice |
| Black Pepper Essential Oil | 📋 | | ⛔ | | 33997409 | Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum Linn. (Black pepper) in mice: involvement of serotonergic but not GABAergic transmission system |
| Casein Protein | 📋 | ✍ | ⛔ | | 36245498 | The anti-anxiety/depression effect of a combined complex of casein hydrolysate and γ-aminobutyric acid on C57BL/6 mice |
| Cashew | 📋 | | ⛔ | | 38002521 | Cashew ( Anacardium occidentale) Extract: Possible Effects on Hypothalamic-Pituitary-Adrenal (HPA) Axis in Modulating Chronic Stress |
| Celery | 📋 | | ⛔ | | 40430359 | Exploring the Neuroprotective Properties of Celery (Apium graveolens Linn) Extract Against Amyloid-Beta Toxicity and Enzymes Associated with Alzheimer's Disease |
| Chicoric Acid | 📋 | | | | 38542381 | Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models |
| Chondroitin | 📋 | ✍ | ⛔ | | 35923649 | Risk of ischaemic stroke among new users of glucosamine and chondroitin sulphate: a nested case-control study |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 35359846 | Metabonomics Study in Mice With Learning and Memory Impairment on the Intervention of Essential Oil Extracted From Cinnamomum camphora Chvar. Borneol |
| Corn Silk | 📋 | ✍ | ⛔ | | 37563784 | Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation |
| D-Mannose | 📋 | ✍ | ⛔ | | 35490896 | Mannose inhibits proliferation and promotes apoptosis to enhance sensitivity of glioma cells to temozolomide through Wnt/β-catenin signaling pathway |
| Diallyl Disulfide | 📋 | | | | 33511484 | Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress |
| Essential Amino Acids | 📋 | ✍ | ⛔ | | 37397466 | A balanced formula of essential amino acids promotes brain mitochondrial biogenesis and protects neurons from ischemic insult |
| Essential Fatty Acids | 📋 | ✍ | | | 32917237 | Important considerations when assessing the effect of essential fatty acids on cognitive performance |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 32522946 | Fish Oil and Primrose Oil Suppress the Progression of Alzheimer's Like Disease Induced by Aluminum in Rats |
| Fatty Acids | 📋 | | | | 36771380 | Dietary Fats and Depressive Symptoms in Italian Adults |
| Frankincense Essential Oil | 📋 | | ⛔ | | 31582666 | The Effects of Frankincense Essential Oil on Stress in Rats |
| Garlic Oil | 📋 | | ⛔ | | 37435927 | Garlic essential oil ameliorates depression-like behaviors in unpredictable chronic mild stress by modulating the brain NLRP3 inflammasome pathway and influencing the gut barrier and microbiota |
| Geranium Essential Oil | 📋 | | ⛔ | | 31490773 | Oral supplementation with geranium oil or anise oil ameliorates depressed rat-related symptoms through oils antioxidant effects |
| Grape Seed Oil | 📋 | | ⛔ | | 32665902 | Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases |
| Hazelnut | 📋 | | ⛔ | | 29208493 | Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents |
| Helichrysum | 📋 | | ⛔ | | 37570911 | Phytochemical Profiling, Antioxidant and Cognitive-Enhancing Effect of Helichrysum italicum ssp. italicum (Roth) G. Don (Asteraceae) |
| HMB | 📋 | ✍ | ⛔ | | 37437568 | Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice |
| Honeysuckle | 📋 | | ⛔ | | 39606633 | Revealing the potential therapeutic mechanism of Lonicerae Japonicae Flos in Alzheimer's disease: a computational biology approach |
| Iron | 📋 | ✍ | ⛔ | | 25837213 | Dietary intake of minerals in relation to depressive symptoms in Japanese employees: the Furukawa Nutrition and Health Study |
| L-Alanine | 📋 | ✍ | ⛔ | | 33626855 | Extremely Low Serum Alanine Transaminase Level Is Associated with All-Cause Mortality in the Elderly after Intracranial Hemorrhage |
| L-Histidine | 📋 | ✍ | ⛔ | | 34836128 | Deficiency in the Essential Amino Acids l-Isoleucine, l-Leucine and l-Histidine and Clinical Measures as Predictors of Moderate Depression in Elderly Women: A Discriminant Analysis Study |
| Lemon Verbena | 📋 | | ⛔ | | 35011093 | Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract |
| Loquat | 📋 | ✍ | ⛔ | | 37513484 | Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice |
| Mango Leaf | 📋 | | ⛔ | | 32717999 | Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study |
| Milk | 📋 | | ⛔ | | 36046132 | Milk intake enhances cerebral antioxidant (glutathione) concentration in older adults: A randomized controlled intervention study |
| Milk Thistle | 📋 | ✍ | ⛔ | | 39534953 | Does a Polyherbal Medicine Enhance Cognition in Healthy Older Adults? An Exploratory Open-Label Study |
| Minerals | 📋 | | | | 37108261 | Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression |
| Myrrh | 📋 | ✍ | ⛔ | | 36280019 | Guggulsterone from Commiphora mukul potentiates anti-glioblastoma efficacy of temozolomide in vitro and in vivo via down-regulating EGFR/PI3K/Akt signaling and NF-κB activation |
| Okra | 📋 | | ⛔ | | 38060590 | Protective and therapeutic effects of okra seed in acute nontraumatic brain injury |
| Omega-9 Fatty Acids | 📋 | | | | 34666393 | Selective Toxicity Effect of Fatty Acids Omega-3, 6 and 9 Combination on Glioblastoma Neurons through their Mitochondria |
| Onion | 📋 | ✍ | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Oregano | 📋 | ✍ | ⛔ | | 39676694 | A promising therapeutic potential of Origanum vulgare extract in mitigating ethanol-induced working memory impairments and hippocampal oxidative stress in rats |
| Parsley | 📋 | | ⛔ | | 34173678 | Investigation of possible neuroprotective effects of some plant extracts on brain in bile duct ligated rats |
| Pear | 📋 | | ⛔ | | 34602398 | Determination of anxiolytic and antidepressant like activity of hydro alcoholic fruit extract of Pyrus communis (L.) and its impact on the memory after chronic dosing in animal models |
| Phellodendron | 📋 | ✍ | ⛔ | | 18426577 | Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial |
| Pine Needle Essential Oil | 📋 | ✍ | ⛔ | | 33655878 | Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus |
| Pine Nut | 📋 | | ⛔ | | 37821052 | Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease |
| Plum | 📋 | | ⛔ | | 30577585 | Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential Oils as Antioxidant and of Cholinesterases Inhibitors |
| Poria Mushrooms | 📋 | ✍ | | | 40254847 | Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty Acids and Alleviate Neuroinflammation-Related Cognitive Impairment in Alzheimer's Disease |
| Protein | 📋 | ✍ | ⛔ | | 38674911 | Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60 |
| Pumpkin | 📋 | | ⛔ | | 34336111 | L. Cucurbita pepo Alleviates Chronic Unpredictable Mild Stress via Modulation of Apoptosis, Neurogenesis, and Gliosis in Rat Hippocampus |
| Rosavin | 📋 | | ⛔ | | 37758932 | Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model |
| Rose | 📋 | | | | 37078068 | Effect of Rosa damascena Extract on Rat Model Alzheimer's Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study |
| Rose Essential Oil | 📋 | | | | 38688895 | A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats |
| Serrapeptase | 📋 | ✍ | ⛔ | | 35694981 | The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach |
| Sesame Oil | 📋 | | ⛔ | | 33049345 | Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways |
| Sirtuin Activators | 📋 | | | | 40300682 | Role of sirtuins in cerebral ischemia-reperfusion injury: Mechanisms and therapeutic potential |
| Sorghum | 📋 | | ⛔ | | 38740315 | The identification of active compounds and therapeutic properties of fermented and non-fermented red sorghum for the treatment of Alzheimer's dementia |
| Soy Protein | 📋 | ✍ | ⛔ | | 36561237 | Ameliorating Effect of Standardized Extract From Textured Soy Protein ( Glycine max L.) on Memory Deficit and Learning Insufficiency in Scopolamine-induced Amnesia |
| Spices | 📋 | | | | 34279199 | Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease |
| Sweet Potato | 📋 | | ⛔ | | 35720655 | Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction |
| Theobromine | 📋 | ✍ | ⛔ | | 31010016 | Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats |
| Thyme | 📋 | ✍ | ⛔ | | 38039009 | Effects of orally administered Thymus vulgaris leaves on memory, anxiety, depression, and sleep quality in university students: a randomized controlled trial |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 30574050 | Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 36208821 | Coriolus versicolor and its bioactive molecule are potential immunomodulators against cancer cell metastasis via inactivation of MAPK pathway |
| UDCA | 📋 | ✍ | ⛔ | | 37989444 | Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO |
| Vegetables | 📋 | | | | 35307760 | Associations of specific types of fruit and vegetables with perceived stress in adults: the AusDiab study |
| White Fungus | 📋 | | | | 40263235 | Tremella fuciformis Polysaccharides Alleviate Early Brain Injury in Experimental Subarachnoid Hemorrhage by Inhibiting the KDR-Mediated P38 MAPK/NF-?B Pathway |
| White Mushrooms | 📋 | | ⛔ | | 36291298 | White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease |
| Wine | 📋 | | ⛔ | | 38901216 | Combined Effect of Red Wine and Mocha Pot Coffee in Mild Vascular Cognitive Impairment |
| Yiang Yiang Essential Oil | 📋 | | ⛔ | | 17211115 | [The effects of the inhalation method using essential oils on blood pressure and stress responses of clients with essential hypertension] |
| Amygdalin | 📋 | ✍ | ⛔ | | 40081511 | Amygdalin's neuroprotective effects on acute ischemic stroke in rats |
| Apricot | 📋 | | ⛔ | | 31550185 | Trans-Himalayan Phytococktail Confers Protection Against Hypobaric Hypoxia-Induced Hippocampal Neurodegeneration and Memory Impairment in Male Sprague Dawley Rats |
| Argan Oil | 📋 | ✍ | ⛔ | | 39408860 | Behavioral and Amygdala Biochemical Damage Induced by Alternating Mild Stress and Ethanol Intoxication in Adolescent Rats: Reversal by Argan Oil Treatment? |
| Arjuna | 📋 | ✍ | ⛔ | | 36234986 | Neuroprotective Effect of Polyphenol Extracts from Terminalia chebula Retz. against Cerebral Ischemia-Reperfusion Injury |
| Avocado Oil | 📋 | | ⛔ | | 26180820 | Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats |
| Bamboo | 📋 | ✍ | ⛔ | | 38334213 | The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model |
| Barberry | 📋 | ✍ | ⛔ | | 36186093 | Neuroprotective Effect of Root Extracts of Berberis Vulgaris (Barberry) on Oxidative Stress on SH-SY5Y Cells |
| Brazil Nut | 📋 | | ⛔ | | 25567069 | Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial |
| Bread | 📋 | | | | 38528644 | Sourdough bread as nutritional intervention tool for improvement of cognitive dysfunction in diabetic rats |
| Broccoli | 📋 | | ⛔ | | 37839110 | The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model |
| Buckwheat | 📋 | | ⛔ | | 39019369 | Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl3-treated rats |
| Camphor Essential Oil | 📋 | | ⛔ | | 38621882 | [Essential oil of Cinnamomum camphora mitigates depression-like behavior in mice by regulating Nrf2/HO-1 pathway and inhibiting inflammatory cytokines] |
| Carrot | 📋 | | ⛔ | | 16755009 | Pharmacological evidence for the potential of Daucus carota in the management of cognitive dysfunctions |
| Cedarwood Essential Oil | 📋 | ✍ | ⛔ | | 32037737 | Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia |
| Chebulinic Acid | 📋 | | | | 37453379 | Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses |
| Chromium | 📋 | ✍ | ⛔ | | 40345207 | The Potential Benefits of Chromium and Selenium Supplementation Across Psychiatric Disorders and Symptoms |
| Citrus Fruits | 📋 | | ⛔ | | 34266770 | Poncirin ameliorates oxygen glucose deprivation/reperfusion injury in cortical neurons via inhibiting NOX4-mediated NLRP3 inflammasome activation |
| Dairy | 📋 | | | | 35947163 | Associations between total dairy, high-fat dairy and low-fat dairy intake, and depressive symptoms: findings from a population-based cross-sectional study |
| Delphinidin | 📋 | | | | 40542425 | Delphinidin attenuates cognitive deficits and pathology of Alzheimer's disease by preventing microglial senescence via AMPK/SIRT1 pathway |
| Diallyl Trisulfide | 📋 | | | | 35921994 | Diallyl trisulfide sensitizes radiation therapy on glioblastoma through directly targeting thioredoxin 1 |
| Docosapentaenoic Acid | 📋 | ✍ | | | 33178186 | The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models |
| Eclipta Alba | 📋 | ✍ | | | 38562322 | Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models |
| Eggplant | 📋 | | ⛔ | | 34994925 | Effect of Solanum vegetables on memory index, redox status, and expressions of critical neural genes in Drosophila melanogaster model of memory impairment |
| Fat | 📋 | | | | 36986159 | Dietary Fats and Cognitive Status in Italian Middle-Old Adults |
| Fennel | 📋 | ✍ | ⛔ | | 32491286 | Protective effect of fennel, and its major component trans-anethole against social isolation induced behavioral deficits in rats |
| Fir Needle Oil | 📋 | | ⛔ | | 36429972 | Relaxing Effects of Breathing Pseudotsuga menziesii and Lavandula angustifolia Essential Oils on Psychophysiological Status in Older Adults |
| Fufang Danshen | 📋 | | | | 29770796 | Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 32439412 | GAMMA-LINOLENIC ACID ALTERS MIGRATION, PROLIFERATION AND APOPTOSIS IN HUMAN AND RAT GLIOBLASTOMA CELLS |
| Geraniin | 📋 | | | | 35222793 | Geraniin Protects against Cerebral Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Neuronal Apoptosis via Regulation of the Nrf2/HO-1 Pathway |
| Ginger Essential Oil | 📋 | ✍ | | | 19285110 | Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice |
| Glutathione | 📋 | ✍ | ⛔ | | 35310529 | Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease |
| Glycyrrhetinic Acid | 📋 | | | | 38964451 | Glycyrrhetinic Acid Triggers a Protective Autophagy by Inhibiting the JAK2/STAT3 Pathway in Cerebral Ischemia/Reperfusion Injury |
| Grapefruit | 📋 | | ⛔ | | 36500599 | Recovery of Naringin-Rich Flavonoid Extracts from Agroresidues with Anxiolytic- and Antidepressant-like Effects in Mice |
| Grapefruit Essential Oil | 📋 | ✍ | ⛔ | | 33463729 | Effects of diffused essential oils for reducing stress and improving mood for clinical nurses: An interventional time series study |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 37283121 | Flavonoids from Citrus paradise cv. Changshan-huyou exerts protective effect on ischemia-induced cerebral injury in mice via inhibiting RhoA-ROCK2 signaling pathway |
| Graviola | 📋 | ✍ | ⛔ | | 39906616 | Scopolamine-induced memory impairment in mice: Soursop leaf extract and fractions protect the hippocampus and prefrontal cortex |
| Guava | 📋 | | ⛔ | | 36758825 | Psidium guajava induces cytotoxicity in human malignant glioblastoma cell line: Role of reactive oxygen species |
| Hops | 📋 | ✍ | ⛔ | | 35854340 | Humulus japonicus attenuates LPS-and scopolamine-induced cognitive impairment in mice |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 32213158 | Hyaluronic Acid and Regenerative Medicine: New Insights Into the Stroke Therapy |
| Hyssop | 📋 | ✍ | ⛔ | | 35963984 | The Effects of Methanol Extracts of Hyssopus officinalis on Model of Induced Glioblastoma Multiforme (GBM) in Rats |
| Iodine | 📋 | ✍ | ⛔ | | 32802419 | The Relationship between Iodine and Selenium Levels with Anxiety and Depression in Patients with Euthyroid Nodular Goiter |
| Isoflavones | 📋 | ✍ | ⛔ | | 35334883 | The Inverse Correlation of Isoflavone Dietary Intake and Headache in Peri- and Post-Menopausal Women |
| Jasmine Essential Oil | 📋 | | | | 33723134 | In vitro cytotoxicity of cardamom oil, lemon oil, and jasmine oil on human skin, gastric, and brain cancer cell line |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 20217640 | Protective effect of Labisia pumila on stress-induced behavioral, biochemical, and immunological alterations |
| Kava Root | 📋 | ✍ | ⛔ | | 11536390 | Kava and valerian in the treatment of stress-induced insomnia |
| Kiwifruit | 📋 | ✍ | ⛔ | | 34831142 | Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis |
| Knotweed | 📋 | ✍ | ⛔ | | 39909363 | Exploring the mechanism of Polygonum Cuspidatum in the treatment of ischemic stroke by network pharmacology analysis and experimental validation |
| Kombucha | 📋 | ✍ | ⛔ | | 37402035 | Chronic Kombucha Beverage Consumption Attenuates Inflammatory Markers and Histopathology of Brain Tissue in Transnet Global Brain Ischemia in Rats |
| L-Carnitine Tartrate | 📋 | ✍ | ⛔ | | 36703196 | Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial |
| L-Proline | 📋 | ✍ | ⛔ | | 27031721 | A Nutrient Mixture Inhibits Glioblastoma Xenograft U-87 MG Growth in Male Nude Mice |
| L-Tyrosine | 📋 | ✍ | ⛔ | | 10023508 | A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria |
| Laminaria | 📋 | ✍ | ⛔ | | 35394414 | Polysaccharides from laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 24745610 | Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells |
| Lemongrass | 📋 | ✍ | ⛔ | | 28499312 | Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice |
| Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 29501481 | Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule |
| Lettuce | 📋 | | ⛔ | | 35101010 | In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa |
| Limonin | 📋 | | | | 25864108 | A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway |
| Madecassoside | 📋 | | | | 32721993 | Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Centella asiatica |
| Manganese | 📋 | ✍ | ⛔ | | 35369103 | Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies |
| Marigold | 📋 | ✍ | ⛔ | | 26120230 | Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats |
| Marjoram | 📋 | | ⛔ | | 33266220 | Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice |
| MSM | 📋 | ✍ | ⛔ | | 35203043 | Methylsulfonylmethane protects against ethanol-induced brain injury in mice through the inhibition of oxidative stress, proinflammatory mediators and apoptotic cell death |
| Mugwort | 📋 | | ⛔ | | 38893336 | In Vitro and In Silico Anti-Glioblastoma Activity of Hydroalcoholic Extracts of Artemisia annua L. and Artemisia vulgaris L |
| Neem | 📋 | ✍ | | | 35198760 | Anxiolytic and antidepressant-like activities of aqueous extract of Azadirachta indica A. Juss. flower in the stressed rats |
| Neroli Essential Oil | 📋 | ✍ | ⛔ | | 40368523 | The effect of aromatherapy with Citrus Aurantium essential oil on depression, stress and anxiety in pregnant women; a randomized controlled clinical trial |
| Nimbolide | 📋 | | | | 38036978 | In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma |
| Nitrate | 📋 | ✍ | ⛔ | | 37331149 | Habitual dietary nitrate intake and cognition in the Australian Imaging, Biomarkers and Lifestyle Study of ageing: A prospective cohort study |
| Noni | 📋 | | ⛔ | | 36118093 | Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice |
| Oak Acorn | 📋 | ✍ | ⛔ | | 39408864 | Extraction Condition Optimization, Quantitative Analysis, and Anti-AD Bioactivity Evaluation of Acorn Polyphenols from Quercus variabilis, Quercus aliena, and Quercus dentata |
| Oak Gall | 📋 | ✍ | ⛔ | | 34961052 | Gallotannin-Enriched Fraction from Quercus infectoria Galls as an Antioxidant and Inhibitory Agent against Human Glioblastoma Multiforme |
| Olive | 📋 | ✍ | ⛔ | | 34796529 | Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke-induced depressive-like behaviors in Sprague-Dawley rats |
| Osmanthus | 📋 | ✍ | ⛔ | | 39554370 | The ethanolic extract of Osmanthus fragrans var. thunbergii flowers ameliorates depressive-like behaviors of mice by modulating the serotonin system and suppressing neuroinflammation |
| Pantethine | 📋 | ✍ | ⛔ | | 37194410 | Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species |
| Peach | 📋 | | ⛔ | | 35598297 | Single-cell Transcriptomic Analysis Demonstrates the Regulation of Peach Polysaccharides on Circadian Rhythm Disturbance |
| Pecan | 📋 | | ⛔ | | 39945748 | Cognitive function in response to a pecan-enriched meal: a randomized, double-blind, cross-over study in healthy adults |
| Prickly Pear | 📋 | | ⛔ | | 38959603 | The remarkable impact of Opuntia Ficus Indica fruit administration on metabolic syndrome: Correlations between cognitive functions, oxidative stress and lipid dysmetabolism in the high-fat, diet-fed rat model |
| Proanthocyanidins | 📋 | | | | 23523627 | Identification of oligomer proanthocyanidins (F2) isolated from grape seeds as a formyl peptide receptor 1 partial agonist |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 35678758 | Vulgarisin-type diterpenoids from self-heal ( Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway |
| Psyllium | 📋 | ✍ | ⛔ | | 31103857 | Intake of Psyllium Seed Husk Reduces White Matter Damage in a Rat Model of Chronic Cerebral Hypoperfusion |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 32992081 | Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation |
| Pueraria Mirifica | 📋 | ✍ | ⛔ | | 26915634 | Neurotherapeutic Effects of Pueraria Mirifica Extract in Early- And Late-Stage Cognitive Impaired Rats |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 37006627 | Cucurbita maxima Seeds Reduce Anxiety and Depression and Improve Memory |
| Quinoa | 📋 | | ⛔ | | 34678977 | Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells |
| Rosehip Seed Oil | 📋 | | ⛔ | | 40158533 | Potential roles of inhalation aromatherapy on stress-induced depression by inhibiting inflammation in the peripheral olfactory system |
| Salt | 📋 | | ⛔ | | 35788204 | Role of no table salt on hypertension and stroke based on large sample size from National Health and Nutrition Examination Survey database |
| Scutellarein | 📋 | | | | 37239029 | A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease |
| Sea Cucumber | 📋 | | | | 38369274 | Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 33541370 | β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis |
| Shugan Hewei Wan | 📋 | | | | 31602893 | [Effects of Shugan Hewei Decoction and active substance fractions on behavior and neurotransmitter levels in hypothalamus of depression model rats] |
| Sodium Bicarbonate | 📋 | ✍ | ⛔ | | 38838426 | Effects of sodium bicarbonate solution on hypergravity-induced Fos expression in neurons of the amygdala in rats: Implication of sodium bicarbonate therapy for vertigo |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 31772594 | Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections |
| Spinach | 📋 | | ⛔ | | 10479711 | Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits With Blueberry, Spinach, or Strawberry Dietary Supplementation |
| St. Johns Wort Oil | 📋 | | ⛔ | | 39840562 | Cytotoxic effects of Hypericum perforatum on Glioblastoma Cells by Inducing Oxidative Stress, Autophagy and Apoptosis |
| Tamarind | 📋 | | ⛔ | | 35481086 | The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches |
| Tangerine | 📋 | | ⛔ | | 35100035 | Effects of Citrus depressa Hayata Fruit Extract on Thigh Muscles Mass and Composition in Subacute Stroke Patients: A Double-Blind, Randomized, Controlled Pilot Trial |
| Tea Polysaccharides | 📋 | | | | 40209346 | Effects of tea polyphenols and tea polysaccharides on improving nonylphenol-induced depression-like behavior, monoamine neurotransmitter disorder, and neuronal pyroptosis |
| Tea Tree Essential Oil | 📋 | | ⛔ | | 33468026 | Natural substances to potentiate canonical glioblastoma chemotherapy |
| Theabrownins | 📋 | | | | 33995088 | Theabrownin Induces Cell Apoptosis and Cell Cycle Arrest of Oligodendroglioma and Astrocytoma in Different Pathways |
| Tomato | 📋 | | ⛔ | | 25613481 | Tomato thymidine kinase-based suicide gene therapy for malignant glioma--an alternative for Herpes Simplex virus-1 thymidine kinase |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 36339275 | A Randomized, Double-Blind, Controlled Clinical Trial of Omega-3 Fatty Acids and Inositol as Monotherapies and in Combination for the Treatment of Pediatric Bipolar Spectrum Disorder in Children Age 5-12 |
| Vitamin K1 | 📋 | ✍ | ⛔ | | 35660920 | Inverse association between plasma phylloquinone and risk of ischemic stroke in Chinese adults with hypertension and high body mass index: a nested case-control study |
| Wasabi | 📋 | | ⛔ | | 37960261 | Benefits of Wasabi Supplements with 6-MSITC (6-Methylsulfinyl Hexyl Isothiocyanate) on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial |
| Xylitol | 📋 | ✍ | ⛔ | | 36154609 | Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice |
| Yerba Mate | 📋 | ✍ | ⛔ | | 40512339 | Caffeinated and Decaffeinated Yerba Mate (Ilex paraguariensis) Infusion Extracts Alter CD73 and Reduce the Migration and Adhesion of Glioblastoma Cells |
| Yogurt | 📋 | | ⛔ | | 39299595 | Association of probiotics, prebiotics, synbiotics or yogurt supplement with prevalence and all-cause mortality of depression: NHANES 2005-2016 |
| Yohimbine | 📋 | ✍ | | | 34889886 | Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments |
| Zingerone | 📋 | | | | 35639359 | Protective Effects of Zingerone Against Depression-Like Behavior and Biochemical Changes in Chronic Stressed Rats: Antioxidant Effects |
